Literature DB >> 1384626

Comparison of cytosolic products formed in rat liver in response to parenteral and dietary iron loading.

P L Ringeling1, M I Cleton, M I Huijskes-Heins, W C de Bruijn, H G van Eijk.   

Abstract

Two different methods were used to create a situation of iron (Fe) overload in rats. One group of rats received Fe dextran, and another group of rats received a carbonyl Fe-enriched diet. The ferritins present in the liver cytosol of these rats were isolated and compared. From each group, two cytosolic products were isolated with the use of ultracentrifugation: a cytosolic ferritin fraction (CF) and a (slower sedimenting) light ferritin fraction (CLF). There were no differences with respect to the protein coat (subunit composition and amino acid analysis). Analysis of the Fe core revealed that the two CF fractions were similar, whereas the two CLF fractions differed with respect to their Fe content and to the packing of their cores. The carbonyl CLF product contained less Fe atoms/molecule, which, moreover, seemed to be packed in a less compact way.

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Year:  1992        PMID： 1384626     DOI： 10.1007/BF02786236

Source DB:  PubMed          Journal:  Biol Trace Elem Res        ISSN： 0163-4984            Impact factor:   3.738


  22 in total

1.  Prevalence of hemochromatosis among 11,065 presumably healthy blood donors.

Authors:  C Q Edwards; L M Griffen; D Goldgar; C Drummond; M H Skolnick; J P Kushner
Journal:  N Engl J Med       Date:  1988-05-26       Impact factor: 91.245

2.  Quantitative energy-filtered image analysis in cytochemistry. II. Morphometric analysis of element-distribution images.

Authors:  C W Sorber; J B Van Dort; P C Ringeling; M I Cleton-Soeteman; W C De Bruijn
Journal:  Ultramicroscopy       Date:  1990-01       Impact factor: 2.689

3.  The mobilization of ferritin iron by liver cytosol. A comparison of xanthine and NADH as reducing substrates.

Authors:  R Topham; M Goger; K Pearce; P Schultz
Journal:  Biochem J       Date:  1989-07-01       Impact factor: 3.857

4.  The reliability of the use of para toluene sulfonic acid for simultaneous hydrolysis and quantitation of both N-acetyl-glucosamine and amino acids in human transferrins.

Authors:  H G van Eijk; W L van Noort
Journal:  Clin Chim Acta       Date:  1986-06-30       Impact factor: 3.786

5.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

6.  Effect of iron loading on non-heme iron compounds in different liver cell populations.

Authors:  C P Van Wyk; M Linder-Horowitz; H N Munro
Journal:  J Biol Chem       Date:  1971-02-25       Impact factor: 5.157

7.  Incorporation and release of inorganic phosphate in horse spleen ferritin.

Authors:  A Trefry; P M Harrison
Journal:  Biochem J       Date:  1978-05-01       Impact factor: 3.857

8.  Iron exchange between ferritin and transferrin in vitro.

Authors:  D C Harris
Journal:  Biochemistry       Date:  1978-07-25       Impact factor: 3.162

9.  Siderosomal ferritin. The missing link between ferritin and haemosiderin?

Authors:  S C Andrews; A Treffry; P M Harrison
Journal:  Biochem J       Date:  1987-07-15       Impact factor: 3.857

10.  Ultrastructural observations in the carbonyl iron-fed rat, an animal model for hemochromatosis.

Authors:  T C Iancu; R J Ward; T J Peters
Journal:  Virchows Arch B Cell Pathol Incl Mol Pathol       Date:  1987
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