Literature DB >> 1384475

Detection of endothelin-1 mRNA by RT-PCR in isolated rat renal tubules.

S Uchida1, F Takemoto, E Ogata, K Kurokawa.   

Abstract

A combination of reverse transcription and polymerase chain reaction was utilized to detect baseline endothelin-1 (ET-1) mRNA expressed in renal tubules dissected from rats. 5' and 3' primers were constructed according to human ET-1 genomic DNA. Rat ET-1 mRNA was found to be expressed only in cortical through medullary collecting ducts in addition to glomeruli. Sites for tubular synthesis of ET-1 corroborate well with major ET-1 binding sites along the nephron, indicating autocrine/paracrine role of ET-1 in the renal tubules and supporting a prevailing concept on such function of ET-1 in many differing tissues.

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Year:  1992        PMID： 1384475     DOI： 10.1016/0006-291x(92)92356-3

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  11 in total

Review 1.  Physiology of endothelin and the kidney.

Authors:  Donald E Kohan; Edward W Inscho; Donald Wesson; David M Pollock
Journal:  Compr Physiol       Date:  2011-04       Impact factor: 9.090

Review 2.  Proximal nephron.

Authors:  Jia L Zhuo; Xiao C Li
Journal:  Compr Physiol       Date:  2013-07       Impact factor: 9.090

Review 3.  Regulation of blood pressure and salt homeostasis by endothelin.

Authors:  Donald E Kohan; Noreen F Rossi; Edward W Inscho; David M Pollock
Journal:  Physiol Rev       Date:  2011-01       Impact factor: 37.312

Review 4.  Endothelin and renal ion and water transport.

Authors:  Joshua S Speed; Brandon M Fox; Jermaine G Johnston; David M Pollock
Journal:  Semin Nephrol       Date:  2015-03       Impact factor: 5.299

5.  Endogenous endothelins mediate increased distal tubule acidification induced by dietary acid in rats.

Authors:  D E Wesson
Journal:  J Clin Invest       Date:  1997-05-01       Impact factor: 14.808

6.  Endothelin is an important determinant of renal function in a rat model of acute liver and renal failure.

Authors:  R Anand; D Harry; S Holt; P Milner; M Dashwood; D Goodier; M Jarmulowicz; K Moore
Journal:  Gut       Date:  2002-01       Impact factor: 23.059

7.  Collecting duct-specific knockout of endothelin-1 causes hypertension and sodium retention.

Authors:  Dowhan Ahn; Yuqiang Ge; Peter K Stricklett; Pritmohinder Gill; Deborah Taylor; Alisa K Hughes; Masashi Yanagisawa; Lance Miller; Raoul D Nelson; Donald E Kohan
Journal:  J Clin Invest       Date:  2004-08       Impact factor: 14.808

8.  Prostaglandin E2 abrogates endothelin-induced vasoconstriction in renal outer medullary descending vasa recta of the rat.

Authors:  E P Silldorff; S Yang; T L Pallone
Journal:  J Clin Invest       Date:  1995-06       Impact factor: 14.808

9.  High salt induces autocrine actions of ET-1 on inner medullary collecting duct NO production via upregulated ETB receptor expression.

Authors:  Kelly Anne Hyndman; Courtney Dugas; Alexandra M Arguello; Traci T Goodchild; Kathleen M Buckley; Mariah Burch; Masashi Yanagisawa; Jennifer S Pollock
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2016-06-08       Impact factor: 3.619

Review 10.  The Role of Endothelin and Endothelin Antagonists in Chronic Kidney Disease.

Authors:  Rupesh Raina; Abigail Chauvin; Ronith Chakraborty; Nikhil Nair; Haikoo Shah; Vinod Krishnappa; Kirsten Kusumi
Journal:  Kidney Dis (Basel)       Date:  2019-12-18
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