| Literature DB >> 1384133 |
Abstract
Hyaluranate (HA) is a major constituent of synovial fluid, but its concentration and molecular size differ in normal and inflamed joints. HA can induce or inhibit angiogenesis depending on both its size and its concentration. Endothelial-cell endocytose-labeled macromolecular HA and HA oligosaccharides and binding studies have identified an HA-specific receptor on the endothelial cell surface (KD, 10(-10) mol/L; approximately 2,000/cell). The molecular weight of HA-binding proteins was found to be 90 to 125, 78, and 46 kd.Entities:
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Year: 1992 PMID： 1384133 DOI： 10.1016/0049-0172(92)90047-h
Source DB: PubMed Journal: Semin Arthritis Rheum ISSN： 0049-0172 Impact factor: 5.532