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Literature DB >> 13835288

Effect of denervation and of cocaine on the action of sympathomimetic amines.

Abstract

The secretory effect of sympathomimetic amines on the submaxillary gland of cats was increased after section of the chorda tympani (preganglionic, parasympathetic supply). After sympathetic denervation of the gland the secretory response to tyramine and phenylethylamine was absent, the response to dopamine and ephedrine decreased and the response to adrenaline and noradrenaline increased. Large doses of cocaine, given locally into the gland, produced changes similar to those observed after sympathetic denervation. The sensitization towards adrenaline and noradrenaline was obtained with smaller doses. Tyramine did not cause a release of catechols from the suprarenal glands of the cat.

Entities: Chemical Species

Keywords: COCAINE/pharmacology; SYMPATHECTOMY/experimental; SYMPATHOMIMETICS/pharmacology

Mesh：

Substances：

Year: 1960 PMID： 13835288 PMCID： PMC1481929 DOI： 10.1111/j.1476-5381.1960.tb01252.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

7 in total

1. The action of sympathomimetic amines in animals treated with reserpine.

Authors: J H BURN; M J RAND
Journal: J Physiol Date: 1958-12-04 Impact factor: 5.182

2. [Mechanism of potentiation and inhibition of sympathomimetic amines by cocaine and other drugs. II. Inhibition of neurosympathomimetics by cocaine].

Authors: A FLECKENSTEIN; D STOCKLE
Journal: Naunyn Schmiedebergs Arch Exp Pathol Pharmakol Date: 1955

3. [Chromaffin system in the human skin].

Authors: J ADAMS-RAY; H NORDENSTAM
Journal: Lyon Chir Date: 1956

4. [Potentiation and weakening effect of cocaine and other drugs on sympathomimetic amines. I. Sensitization of cat nictitating membrane to sympathomimetics of the pyrocatechol group].

Authors: A FLECKENSTEIN; H BASS
Journal: Naunyn Schmiedebergs Arch Exp Pathol Pharmakol Date: 1953

7. Comparative effects of cocaine and pseudococaine on EEG activities, cardiorespiratory functions, and self-administration behavior in the rhesus monkey.

Authors: M Matsuzaki; P J Spingler; E G Whitlock; A L Misra; S J Mulé
Journal: Psychopharmacology (Berl) Date: 1978-04-14 Impact factor: 4.530

7 in total

Effect of denervation and of cocaine on the action of sympathomimetic amines.

1. The action of sympathomimetic amines in animals treated with reserpine.

2. [Mechanism of potentiation and inhibition of sympathomimetic amines by cocaine and other drugs. II. Inhibition of neurosympathomimetics by cocaine].

3. [Chromaffin system in the human skin].

4. [Potentiation and weakening effect of cocaine and other drugs on sympathomimetic amines. I. Sensitization of cat nictitating membrane to sympathomimetics of the pyrocatechol group].

5. Nicotine-like actions in auricles and blood vessels after denervation.

6. An analysis of the effect of cocaine on the actions of adrenaline and tyramine.

7. Sensitization of the submaxillary gland to chemical stimuli.

1. CATECHOLAMINE RELEASE FROM THE ISOLATED PERFUSED ADRENAL GLAND.

2. CHANGE OF VASOMOTOR RESPONSE TO CATECHOL AMINES ON REPEATED ADMINISTRATION.

3. [Liberation of pyrocatechol amines from the isolated perfused adrenal gland by tyramine and beta-phenylethylamine].

4. Effects of sympathectomy on the in vitro alpha and beta-responses of the parotid gland.

5. A study of the release of catecholamines from the adrenal medulla by indirectly acting sympathomimetic amines.

6. [On the effect of tyramine on the isolated intestine].

7. Comparative effects of cocaine and pseudococaine on EEG activities, cardiorespiratory functions, and self-administration behavior in the rhesus monkey.