Literature DB >> 1383388

Soluble intercellular adhesion molecule 1-immunoglobulin G1 immunoadhesin mediates phagocytosis of malaria-infected erythrocytes.

D E Staunton1, C F Ockenhouse, T A Springer.   

Abstract

We describe an immunoadhesin molecule containing intercellular adhesion molecule 1 (ICAM-1) molecularly fused to hinge and CH2 and CH3 domains of the human immunoglobulin G1 H chain that binds Plasmodium falciparum-infected erythrocytes. This receptor-based immunoadhesin is an effective and specific inhibitor of P. falciparum-infected erythrocyte adhesion to ICAM-1-bearing surfaces, but does not inhibit leukocyte function antigen 1 (LFA-1) interaction with ICAM-1. Furthermore, the immunoadhesin promotes phagocytosis and destruction of parasitized erythrocytes by human monocytes. Each of these modes of action has potential for the therapy of malaria.

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Year:  1992        PMID： 1383388      PMCID： PMC2119430          DOI： 10.1084/jem.176.5.1471

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  15 in total

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Authors:  T A Springer
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5.  Binding of the integrin Mac-1 (CD11b/CD18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylation.

Authors:  M S Diamond; D E Staunton; S D Marlin; T A Springer
Journal:  Cell       Date:  1991-06-14       Impact factor: 41.582

6.  Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1).

Authors:  S D Marlin; T A Springer
Journal:  Cell       Date:  1987-12-04       Impact factor: 41.582

7.  Molecular basis of sequestration in severe and uncomplicated Plasmodium falciparum malaria: differential adhesion of infected erythrocytes to CD36 and ICAM-1.

Authors:  C F Ockenhouse; M Ho; N N Tandon; G A Van Seventer; S Shaw; N J White; G A Jamieson; J D Chulay; H K Webster
Journal:  J Infect Dis       Date:  1991-07       Impact factor: 5.226

8.  A cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses.

Authors:  D E Staunton; V J Merluzzi; R Rothlein; R Barton; S D Marlin; T A Springer
Journal:  Cell       Date:  1989-03-10       Impact factor: 41.582

9.  The binding site on ICAM-1 for Plasmodium falciparum-infected erythrocytes overlaps, but is distinct from, the LFA-1-binding site.

Authors:  A R Berendt; A McDowall; A G Craig; P A Bates; M J Sternberg; K Marsh; C I Newbold; N Hogg
Journal:  Cell       Date:  1992-01-10       Impact factor: 41.582

10.  Structural and binding analysis of a two domain extracellular CD2 molecule.

Authors:  P H Sayre; R E Hussey; H C Chang; T L Ciardelli; E L Reinherz
Journal:  J Exp Med       Date:  1989-03-01       Impact factor: 14.307
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  8 in total

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2.  Functional studies of truncated soluble intercellular adhesion molecule 1 expressed in Escherichia coli.

Authors:  S Martin; A Martin; D E Staunton; T A Springer
Journal:  Antimicrob Agents Chemother       Date:  1993-06       Impact factor: 5.191

3.  Efficient neutralization and disruption of rhinovirus by chimeric ICAM-1/immunoglobulin molecules.

Authors:  S Martin; J M Casasnovas; D E Staunton; T A Springer
Journal:  J Virol       Date:  1993-06       Impact factor: 5.103

4.  Upregulation of ICAM-I by Plasmodium falciparum: in vitro and in vivo studies.

Authors:  W Graninger; J Prada; S Neifer; G Zotter; F Thalhammer; P G Kremsner
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5.  Soluble endothelium-associated adhesion molecules in patients with Graves' disease.

Authors:  C Wenisch; D Myskiw; B Parschalk; T Hartmann; K Dam; W Graninger
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6.  Brugia malayi microfilariae adhere to human vascular endothelial cells in a C3-dependent manner.

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7.  Residues within a conserved amino acid motif of domains 1 and 4 of VCAM-1 are required for binding to VLA-4.

Authors:  R H Vonderheide; T F Tedder; T A Springer; D E Staunton
Journal:  J Cell Biol       Date:  1994-04       Impact factor: 10.539

Review 8.  Anti-infective immunoadhesins from plants.

Authors:  Keith Wycoff; James Maclean; Archana Belle; Lloyd Yu; Y Tran; Chad Roy; Frederick Hayden
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  8 in total

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