Literature DB >> 13831267

Suppression of experimental "allergic" encephalomyelitis in guinea pigs by encephalitogenic proteins extracted from homologous brain.

C M SHAW, W J FAHLBERG, M W KIES, E C ALVORD.   

Abstract

The intradermal injection of aqueous solutions of certain homologous neural proteins will suppress the encephalomyelitis which is induced in guinea pigs by the previous injection of whole homologous brain with Freund's adjuvants. These neural proteins extracted by dilute acid from defatted guinea pig brain are themselves highly encephalitogenic when injected with adjuvants, but the specificity of this suppression for encephalitogenic as compared to non-encephalitogenic extracts remains to be proven. Suppression is probably not due to a non-specific stress reaction, as indicated by the absence of suppression by intradermal injections of alcohol and by statistically insignificant and inconstant effects of similar injections of tuberculin.

Entities:  

Keywords:  BRAIN/chemistry; ENCEPHALOMYELITIS/experimental; PROTEINS/pharmacology

Mesh：

Substances：

Year:  1960        PMID： 13831267      PMCID： PMC2137257          DOI： 10.1084/jem.111.2.171

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  11 in total

1.  [Prevention of allergic encephalomyelitis by prior injection of adjuvants].

Authors:  M W KIES; E C ALVORD
Journal:  Nature       Date:  1958-10-18       Impact factor: 49.962

2.  Clinico-pathologic correlations in experimental allergic encephalomyelitis. II. Development of an index for quantitative assay of encephalitogenic activity of antigens.

Authors:  E C ALVORD; M W KIES
Journal:  J Neuropathol Exp Neurol       Date:  1959-07       Impact factor: 3.685

3.  [Role of killed tubercle bacillus in the pathogenesis of so-called allergic encephalomyelitis induced by brain extract plus Freund's adjuvants].

Authors:  N CONSTANTINESCO; T HORNET; N BIRZU; O ZAVATE; I PENCEA; S RUSAN
Journal:  Ann Inst Pasteur (Paris)       Date:  1959-01

4.  Further study of skin reactions in rabbits with experimental allergic encephalomyelitis: reactions to tests with purified white matter fractions; use of a quantitative technique for evaluating sensitivity production of sensitization and disease by intradermal injection of antigen without adjuvants.

Authors:  B H WAKSMAN
Journal:  J Infect Dis       Date:  1956 Nov-Dec       Impact factor: 5.226

5.  Experimental allergic encephalomyelitis during and following cortone acetate treatment.

Authors:  A FERRARO; L ROIZIN
Journal:  J Neuropathol Exp Neurol       Date:  1953-10       Impact factor: 3.685

6.  Tuberculin type sensitivity to spinal cord antigen in rabbits with isoallergic encephalomyelitis.

Authors:  B H WAKSMAN; L R MORRISON
Journal:  J Immunol       Date:  1951-04       Impact factor: 5.422

7.  Action of adrenocorticotropic hormone (ACTH) in experimental allergic encephalomyelitis of the guinea pig.

Authors:  A W MOYER; G A JERVIS; J BLACK; H KOPROWSKI; H R COX
Journal:  Proc Soc Exp Biol Med       Date:  1950-11

8.  Studies on acute disseminated encephalomyelitis produced experimentally in rhesus monkeys. VII. The effect of cortisone.

Authors:  E A KABAT; A WOLF; A E BEZER
Journal:  J Immunol       Date:  1952-03       Impact factor: 5.422

9.  Experimental studies in allergic encephalomyelitis; prevention and production.

Authors:  A FERRARO; L ROIZIN; C L CAZZULLO
Journal:  J Neuropathol Exp Neurol       Date:  1950-01       Impact factor: 3.685

10.  Prophylactic and therapeutic effect of para-aminobenzoic acid and sodium salicylate on experimental allergic encephalomyelitis.

Authors:  R A GOOD; B CAMPBELL; T A GOOD
Journal:  Proc Soc Exp Biol Med       Date:  1949-11
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  9 in total

1.  Allergic encephalomyelitis and its significance in clinical medicine.

Authors: 
Journal:  Br Med J       Date:  1961-04-22

2.  Suppression of experimental allergic encephalomyelitis in guinea-pigs with poly-L-lysine.

Authors:  E Chelmicka-Szorc; B G Arnason
Journal:  Clin Exp Immunol       Date:  1975-12       Impact factor: 4.330

3.  Immunohistological evidence of perivascular localization of basic protein in early development of experimental allergic encephalomyelitis.

Authors:  J Simon; A P Anzil
Journal:  Acta Neuropathol       Date:  1974-02-07       Impact factor: 17.088

4.  [Organic and functional changes in experimental allergic encephalomyelitis in the rhesus monkey].

Authors:  J Simon; O Simonova
Journal:  Z Neurol       Date:  1971

5.  Allergic encephalomyelitis: immunologically specific inhibition of cellular passive transfer by encephalitogenic basic proteins.

Authors:  S Levine; E M Hoenig; M W Kies
Journal:  Clin Exp Immunol       Date:  1970-04       Impact factor: 4.330

6.  Failure of myelin basic protein to prevent or suppress experimental allergic encephalomyelitis in guinea pigs.

Authors:  G A Hashim
Journal:  Neurochem Res       Date:  1980-02       Impact factor: 3.996

7.  Prevention of experimental allergic encephalomyelitis (EAE) by vitamin C deprivation.

Authors:  P S MUELLER; M W KIES; E C ALVORD; C M SHAW
Journal:  J Exp Med       Date:  1962-02-01       Impact factor: 14.307

8.  Toll-Like Receptor 2 Mediates In Vivo Pro- and Anti-inflammatory Effects of Mycobacterium Tuberculosis and Modulates Autoimmune Encephalomyelitis.

Authors:  Alessia Piermattei; Giuseppe Migliara; Gabriele Di Sante; Maria Foti; Soren Bohos Hayrabedyan; Angela Papagna; Maria Concetta Geloso; Maddalena Corbi; Mariagrazia Valentini; Alessandro Sgambato; Giovanni Delogu; Gabriela Constantin; Francesco Ria
Journal:  Front Immunol       Date:  2016-05-24       Impact factor: 7.561

9.  Critical relationships between constituents of the antigen-adjuvant emulsion affecting experimental allergic encephalomyelitis in a completely susceptible mouse genotype.

Authors:  J M LEE; H A SCHNEIDER
Journal:  J Exp Med       Date:  1962-01-01       Impact factor: 14.307
  9 in total

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