Literature DB >> 1382786

The neuroprotective effect of a nitric oxide inhibitor in a rat model of focal cerebral ischaemia.

A Buisson1, M Plotkine, R G Boulu.   

Abstract

Recent data showed that glutamate toxicity in primary cortical cultures is mediated by nitric oxide. In order to investigate the effect of inhibition of NO synthase on focal cerebral ischaemia in rats, we studied the histological consequences of a middle cerebral artery (MCA) occlusion after post-operative treatment with NG-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthase. We found a significant reduction of cortical (-43%) and striatal (-25%) necrotic volumes induced by MCA occlusion, indicating that NO synthesis plays an important role in the neurotoxic cascade leading to neuronal damage after focal cerebral ischaemia in rats.

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Year:  1992        PMID： 1382786      PMCID： PMC1907643          DOI： 10.1111/j.1476-5381.1992.tb14410.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  9 in total

Review 1.  Nitric oxide as a neuronal messenger.

Authors:  S H Snyder; D S Bredt
Journal:  Trends Pharmacol Sci       Date:  1991-04       Impact factor: 14.819

2.  Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

Authors:  V L Dawson; T M Dawson; E D London; D S Bredt; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-15       Impact factor: 11.205

3.  Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse.

Authors:  J P Nowicki; D Duval; H Poignet; B Scatton
Journal:  Eur J Pharmacol       Date:  1991-11-12       Impact factor: 4.432

Review 4.  Methods for antagonizing glutamate neurotoxicity.

Authors:  D W Choi
Journal:  Cerebrovasc Brain Metab Rev       Date:  1990

5.  The double-edged role of nitric oxide in brain function and superoxide-mediated injury.

Authors:  J S Beckman
Journal:  J Dev Physiol       Date:  1991-01

Review 6.  Glutamate, nitric oxide and cell-cell signalling in the nervous system.

Authors:  J Garthwaite
Journal:  Trends Neurosci       Date:  1991-02       Impact factor: 13.837

7.  Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo.

Authors:  D D Rees; R M Palmer; R Schulz; H F Hodson; S Moncada
Journal:  Br J Pharmacol       Date:  1990-11       Impact factor: 8.739

8.  Continuous nimodipine treatment attenuates cortical infarction in rats subjected to 24 hours of focal cerebral ischemia.

Authors:  M Jacewicz; S Brint; J Tanabe; W A Pulsinelli
Journal:  J Cereb Blood Flow Metab       Date:  1990-01       Impact factor: 6.200

9.  The glutamate antagonist MK-801 reduces focal ischemic brain damage in the rat.

Authors:  C K Park; D G Nehls; D I Graham; G M Teasdale; J McCulloch
Journal:  Ann Neurol       Date:  1988-10       Impact factor: 10.422
  9 in total
  28 in total

1.  Preconditioning with a novel metallopharmaceutical NO donor in anesthetized rats subjected to brain ischemia/reperfusion.

Authors:  Marcio Wilker Soares Campelo; Reinaldo Barreto Oriá; Luiz Gonzaga de França Lopes; Gerly Anne de Castro Brito; Armenio Aguiar dos Santos; Raquel Cavalcante de Vasconcelos; Francisco Ordelei Nascimento da Silva; Beatrice Nuto Nobrega; Moisés Tolentino Bento-Silva; Paulo Roberto Leitão de Vasconcelos
Journal:  Neurochem Res       Date:  2011-12-10       Impact factor: 3.996

Review 2.  Trends and future developments in the pharmacological treatment of acute ischaemic stroke.

Authors:  G J del Zoppo; S Wagner; M Tagaya
Journal:  Drugs       Date:  1997-07       Impact factor: 9.546

3.  Neuroprotective effects of cactus polysaccharide on oxygen and glucose deprivation induced damage in rat brain slices.

Authors:  Xianju Huang; Qin Li; Yingpei Zhang; Qing Lü; Lianjun Guo; Lin Huang; Zhi He
Journal:  Cell Mol Neurobiol       Date:  2007-08-22       Impact factor: 5.046

4.  The effect of chlormethiazole on neuronal damage in a model of transient focal ischaemia.

Authors:  S G Sydserff; A J Cross; K J West; A R Green
Journal:  Br J Pharmacol       Date:  1995-04       Impact factor: 8.739

5.  Spatiotemporal patterns of dexamethasone-induced Ras protein 1 expression in the central nervous system of rats with experimental autoimmune encephalomyelitis.

Authors:  Heng Gao; Ying Gao; Xiaohong Li; Aiguo Shen; Meijuan Yan
Journal:  J Mol Neurosci       Date:  2010-01-19       Impact factor: 3.444

6.  Lysine and arginine reduce the effects of cerebral ischemic insults and inhibit glutamate-induced neuronal activity in rats.

Authors:  Takashi Kondoh; Makiko Kameishi; Hruda Nanda Mallick; Taketoshi Ono; Kunio Torii
Journal:  Front Integr Neurosci       Date:  2010-06-14

7.  Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: antinociceptive and cardiovascular effects.

Authors:  P K Moore; P Wallace; Z Gaffen; S L Hart; R C Babbedge
Journal:  Br J Pharmacol       Date:  1993-09       Impact factor: 8.739

8.  Nitric oxide protects against cellular damage and cytotoxicity from reactive oxygen species.

Authors:  D A Wink; I Hanbauer; M C Krishna; W DeGraff; J Gamson; J B Mitchell
Journal:  Proc Natl Acad Sci U S A       Date:  1993-11-01       Impact factor: 11.205

Review 9.  The emerging multifaceted roles of nitric oxide.

Authors:  P C Kuo; R A Schroeder
Journal:  Ann Surg       Date:  1995-03       Impact factor: 12.969

10.  Attenuated neurotransmitter release and spreading depression-like depolarizations after focal ischemia in mutant mice with disrupted type I nitric oxide synthase gene.

Authors:  M Shimizu-Sasamata; P Bosque-Hamilton; P L Huang; M A Moskowitz; E H Lo
Journal:  J Neurosci       Date:  1998-11-15       Impact factor: 6.167
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