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Literature DB >> 138276

The effect of fractionated exposure to thio-TEPA upon Chinese hamster cells in vitro.

Abstract

The dependence of the surviving fraction of Chinese hamster cells in vitro upon the concentration of Thio-TEPA, upon the duration of drug exposure and upon fractionation of drug exposure has been studied. Given a constant exposure time, the surviving fraction decreased according to a "shoulder" curve with increasing concentration. Given a constant concentration, the surviving fraction decreased exponentially with increasing exposure time. Splitting exposure of 60 min into two 30 minutes' exposures with drug-free intervals of several hours increased the cytostatic effect of Thio-TEPA.

Entities: Chemical Species

Mesh：

Substances：
Thiotepa

Year: 1976 PMID： 138276 DOI： 10.1007/bf00506503

Source DB: PubMed Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol ISSN： 0084-5353

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References

12 in total

9. Treatment of leukemia with triethylene thiophosphoramide (thio-TEPA); preliminary results in experimental and clinical leukemia.

Authors: H SHAY; C ZARAFONETIS; N SMITH; I WOLDOW; D C SUN
Journal: AMA Arch Intern Med Date: 1953-11

10. [Local treatment of carcinomatous effusions with triethylenethiophosphoramide (thio-tepa)].

Authors: P Schwandt; H Ehrhart
Journal: Munch Med Wochenschr Date: 1966-12-16

The effect of fractionated exposure to thio-TEPA upon Chinese hamster cells in vitro.

1. Radiation response of mammalian cells grown in culture. 1. Repair of X-ray damage in surviving Chinese hamster cells.

2. Observations on the chromosomes of Chinese hamster cells in tissue culture.

3. Cell cycle phase specificity of antitumor agents.

4. Studies on the lethal effects of sulfur mustard on dividing mammalian cells.

5. Age responses of cultured mammalian cells to cytotoxic drugs.

6. A modification of the sensitivity of mammalian cells surviving treatment with methyl methanesulphonate.

7. X-rays and nitrogen mustard: independent action in Chinese hamster cells.

8. The effects of chemotherapy on the kinetics of leukemic cell behavior.

9. Treatment of leukemia with triethylene thiophosphoramide (thio-TEPA); preliminary results in experimental and clinical leukemia.

10. [Local treatment of carcinomatous effusions with triethylenethiophosphoramide (thio-tepa)].