Literature DB >> 138275

[On the cytostatic mechanism of action of N-methyl-N-beta-chloroethylhydrazine and its benzaldehydhydrazone (author's transl)].

R Braun, U Mangold, R Mangold.   

Abstract

N-Methyl-N-beta-chloroethyl-hydrazine and its bezaldehydhydrazone inhibit the synthesis of DNA and RNA in ascites cells in vitro faster and stronger than N,N-Dimethylhydrazine and procarbazina does. The benzaldehydhydrzone essentially inhibits influx and phosphorylation of nucleosides whereas N-Methyl-N-beta-chloroethylhydrazine acts directly on DNA synthesis.

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Year:  1976        PMID： 138275     DOI： 10.1007/bf00506502

Source DB:  PubMed          Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol        ISSN： 0084-5353


  4 in total

1.  Studies on protein and nucleic acid metabolism in virus-infected mammalian cells. 1. Encephalomyocarditis virus in Krebs II mouse-ascites-tumour cells.

Authors:  E M MARTIN; J MALEC; S SVED; T S WORK
Journal:  Biochem J       Date:  1961-09       Impact factor: 3.857

2.  [Studies on the mechanism of cytostatic action of methylhydrazine, 3].

Authors:  G Weitzel; F Schneider; W D Hirschmann; J Durst; R Thauer; H Ochs; D Kummer
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1967-04

3.  [Cytostatic mechanism of action of methylhydrazine].

Authors:  G Weitzel; F Schneider; A M Fretzdorff
Journal:  Experientia       Date:  1964-01-15

4.  [Studies on the mechanism of cytostatic action of methylhydrazine, II].

Authors:  G Weitzel; F Schneider; A M Fretzdorff; J Durst; W D Hirschmann
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1967-04
  4 in total
  4 in total

1.  [The immunosuppressive effects of N-methyl-N'-beta-chlorethylhydrazones].

Authors:  D Gericke; R Braun
Journal:  Naturwissenschaften       Date:  1977-01

2.  [The anti-leukemic and immunosuppressive effect of methylhydrazones].

Authors:  R Braun; W Dittmar
Journal:  Naturwissenschaften       Date:  1978-05

3.  In vitro and in vivo investigations for the development of cytostatic methylhydrazones.

Authors:  W Dittmar; G Klitschka; R Braun; F Ali-Osman; C Meckert; H R Maurer
Journal:  J Cancer Res Clin Oncol       Date:  1985       Impact factor: 4.553

4.  [The influence of cytostatic and immunosuppressive methyl hydrazones on myelo- and lymphopoiesis in vitro (author's transl)].

Authors:  H R Maurer; R Maschler; R Braun; W Dittmar
Journal:  J Cancer Res Clin Oncol       Date:  1979-10       Impact factor: 4.553
  4 in total

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