Literature DB >> 1382603

Mapping of the epitope on lipoprotein lipase recognized by a monoclonal antibody (5D2) which inhibits lipase activity.

M S Liu1, Y Ma, M R Hayden, J D Brunzell.   

Abstract

A monoclonal antibody, 5D2, which inhibits human lipoprotein lipase (hLPL) activity has been widely used for assessment of LPL immunoreactive mass in the clinical evaluation of patients [1] and for analysis of structure-function relationships of LPL [2,3]. We have mapped the epitope on LPL, recognized by the 5D2 antibody, within residues 396-405. Ala400 is the critical amino acid residue conferring epitope specificity. This knowledge confirms that the C-terminal domain of LPL plays a critical role in LPL activity and also provides important information for studies exploring the structure-function relationship of LPL using this antibody.

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Year:  1992        PMID： 1382603     DOI： 10.1016/0005-2760(92)90264-v

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  12 in total

1.  Mutations in lipoprotein lipase that block binding to the endothelial cell transporter GPIHBP1.

Authors:  Constance V Voss; Brandon S J Davies; Shelly Tat; Peter Gin; Loren G Fong; Christopher Pelletier; Charlene D Mottler; André Bensadoun; Anne P Beigneux; Stephen G Young
Journal:  Proc Natl Acad Sci U S A       Date:  2011-04-25       Impact factor: 11.205

2.  A new monoclonal antibody, 4-1a, that binds to the amino terminus of human lipoprotein lipase.

Authors:  André Bensadoun; Charlene D Mottler; Chris Pelletier; Daniel Wu; Jane J Seo; Calvin S Leung; Oludotun Adeyo; Chris N Goulbourne; Peter Gin; Loren G Fong; Stephen G Young; Anne P Beigneux
Journal:  Biochim Biophys Acta       Date:  2014-03-28

3.  An LPL-specific monoclonal antibody, 88B8, that abolishes the binding of LPL to GPIHBP1.

Authors:  Christopher M Allan; Mikael Larsson; Xuchen Hu; Cuiwen He; Rachel S Jung; Alaleh Mapar; Constance Voss; Kazuya Miyashita; Tetsuo Machida; Masami Murakami; Katsuyuki Nakajima; André Bensadoun; Michael Ploug; Loren G Fong; Stephen G Young; Anne P Beigneux
Journal:  J Lipid Res       Date:  2016-08-05       Impact factor: 5.922

4.  Not the mature 56 kDa lipoprotein lipase protein but a 37 kDa protein co-purifying with the lipase mediates the binding of low density lipoproteins to J774 macrophages.

Authors:  W L Hendriks; L C Van Vark; K Schoonderwoerd; H Jansen; L M Havekes
Journal:  Biochem J       Date:  1998-03-01       Impact factor: 3.857

5.  Unfolding of monomeric lipoprotein lipase by ANGPTL4: Insight into the regulation of plasma triglyceride metabolism.

Authors:  Kristian K Kristensen; Katrine Zinck Leth-Espensen; Haydyn D T Mertens; Gabriel Birrane; Muthuraman Meiyappan; Gunilla Olivecrona; Thomas J D Jørgensen; Stephen G Young; Michael Ploug
Journal:  Proc Natl Acad Sci U S A       Date:  2020-02-07       Impact factor: 11.205

6.  Binding preferences for GPIHBP1, a glycosylphosphatidylinositol-anchored protein of capillary endothelial cells.

Authors:  Peter Gin; Anne P Beigneux; Constance Voss; Brandon S J Davies; Jennifer A Beckstead; Robert O Ryan; André Bensadoun; Loren G Fong; Stephen G Young
Journal:  Arterioscler Thromb Vasc Biol       Date:  2010-10-21       Impact factor: 8.311

Review 7.  GPIHBP1, an endothelial cell transporter for lipoprotein lipase.

Authors:  Stephen G Young; Brandon S J Davies; Constance V Voss; Peter Gin; Michael M Weinstein; Peter Tontonoz; Karen Reue; André Bensadoun; Loren G Fong; Anne P Beigneux
Journal:  J Lipid Res       Date:  2011-08-15       Impact factor: 5.922

8.  Gene-environment interaction in the conversion of a mild-to-severe phenotype in a patient homozygous for a Ser172-->Cys mutation in the lipoprotein lipase gene.

Authors:  Y Ma; M S Liu; D Ginzinger; J Frohlich; J D Brunzell; M R Hayden
Journal:  J Clin Invest       Date:  1993-05       Impact factor: 14.808

9.  The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase.

Authors:  John G Luz; Anne P Beigneux; DeeAnn K Asamoto; Cuiwen He; Wenxin Song; Christopher M Allan; Jazmin Morales; Yiping Tu; Adam Kwok; Thomas Cottle; Muthuraman Meiyappan; Loren G Fong; Judy E Kim; Michael Ploug; Stephen G Young; Gabriel Birrane
Journal:  J Lipid Res       Date:  2020-07-20       Impact factor: 5.922

10.  The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries.

Authors:  Chris N Goulbourne; Peter Gin; Angelica Tatar; Chika Nobumori; Andreas Hoenger; Haibo Jiang; Chris R M Grovenor; Oludotun Adeyo; Jeffrey D Esko; Ira J Goldberg; Karen Reue; Peter Tontonoz; André Bensadoun; Anne P Beigneux; Stephen G Young; Loren G Fong
Journal:  Cell Metab       Date:  2014-04-10       Impact factor: 27.287
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