| Literature DB >> 1382173 |
R Invernizzi1, P De Fazio, A M Iannone, L M Zambelli, M P Rastaldi, G Ippoliti, E Ascari.
Abstract
Factor XIII (FXIII) is a plasma pro-transglutaminase consisting of A and B subunits in a tetrameric structure. A cellular form of FXIII consisting exclusively of A subunits exists in platelets and monocytes: monocyte FXIII may be involved in connective tissue organization. To evaluate the expression and diagnostic significance of FXIII A subunit (FXIIIA) in acute leukemia, we performed an immunocytochemical study (PAP technique) with rabbit antiserum against FXIIIA on leukemic blasts of 48 cases. FXIIIA was detected only in myelomonocytic (M4), monocytic (M5) and megakaryocytic (M7) cases: in M4 and M5 samples the amount of blast cytoplasmic FXIIIA was closely correlated with the expression of monocyte-specific antigenic and cytochemical markers. Our data show immunocytochemical detection of FXIIIA to be useful for acute leukemia characterization.Entities:
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Year: 1992 PMID： 1382173 DOI： 10.1016/0145-2126(92)90163-2
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156