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Literature DB >> 13821613

Antagonism of the effects of tremorine by tropine derivatives.

Abstract

Methods of testing new drugs for anti-Parkinson activity are briefly reviewed. The production in animals of Parkinson-like effects by Tremorine (1,4-dipyrrolidin-1'-ylbut-2-yne), and the inhibition of these effects in mice by a number of tropine derivatives, are described. No correlation was found between the activity against tremor and the anticholinergic, antihistaminic or local anaesthetic properties of the compounds.

Entities: Chemical Disease Species

Keywords: HETEROCYCLIC COMPOUNDS/pharmacology; PARASYMPATHOLYTICS/pharmacology; TREMOR/experimental

Mesh：

Substances：

Year: 1959 PMID： 13821613 PMCID： PMC1481897 DOI： 10.1111/j.1476-5381.1959.tb00964.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

12 in total

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Authors: E M TRAUTNER; S GERSHON
Journal: Nature Date: 1959-05-23 Impact factor: 49.962

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Authors: E FROMMEL
Journal: Presse Med Date: 1958-11-08 Impact factor: 1.228

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Authors: M CRITCHLEY
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Authors: L J DOSHAY
Journal: J Am Med Assoc Date: 1956-11-10

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Authors: K R UNNA; V G VERNIER
Journal: Ann N Y Acad Sci Date: 1956-11-16 Impact factor: 5.691

6. Tremor produced by drugs.

Authors: G M EVERETT
Journal: Nature Date: 1956-06-30 Impact factor: 49.962

7. Bulbar reticular formation and tremor.

Authors: F L JENKNER; A WARD
Journal: AMA Arch Neurol Psychiatry Date: 1953-10

8. Nicotinolytic drugs. II. Action of adrenergic blocking agents on nicotine-induced tremors.

Authors: R L CAHEN; J M THOMAS; K M TVEDE
Journal: J Pharmacol Exp Ther Date: 1953-04 Impact factor: 4.030

9. Assay of histamine on the isolated guinea-pig intestine by the method of superfusion.

Authors: H M ADAM; D C HARDWICK; K E SPENCER
Journal: Br J Pharmacol Chemother Date: 1954-09

10. The action on nicotine-induced tremors of substances effective in Parkinsonism.

Authors: D BOVET; V G LONGO
Journal: J Pharmacol Exp Ther Date: 1951-05 Impact factor: 4.030

6 in total

1. A REVIEW OF DRUG THERAPY IN PARKINSONISM.

Authors: R C DUVOISIN
Journal: Bull N Y Acad Med Date: 1965-08

2. Effects of cholinoceptor antagonists on the suckling-induced and experimentally evoked release of oxytocin.

Authors: G Clarke; C H Fall; D W Lincoln; L P Merrick
Journal: Br J Pharmacol Date: 1978-07 Impact factor: 8.739

3. Enthalpy-entropy relationship in drug-cholinoceptor interaction: a new approach.

Authors: S Cohen; F Haberman
Journal: Br J Pharmacol Date: 1985-08 Impact factor: 8.739

4. Activity of centrally acting and other drugs against tremor and hypothermia induced in mice by tremorine.

Authors: P S Spencer
Journal: Br J Pharmacol Chemother Date: 1965-10

5. Use of a novel radiometric method to assess the inhibitory effect of donepezil on acetylcholinesterase activity in minimally diluted tissue samples.

Authors: Tatsuya Kikuchi; Toshimitsu Okamura; Takuya Arai; Takayuki Obata; Kiyoshi Fukushi; Toshiaki Irie; Tetsuya Shiraishi
Journal: Br J Pharmacol Date: 2010-04 Impact factor: 8.739

6. 1-Hydroxy-3-amino-pyrrolidone-2(HA-966): a new GABA-like compound, with potential use in extrapyramidal diseases.

Authors: I L Bonta; C J De Vos; H Grijsen; F C Hillen; E L Noach; A W Sim
Journal: Br J Pharmacol Date: 1971-11 Impact factor: 8.739

6 in total