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Literature DB >> 13819366

The relationship of serum gamma-globulin concentration to malaria and sickling.

Abstract

The serum protein patterns of groups of Nigerians including 98 children partially protected by "daraprim" against malaria, and 113 unprotected children, have been studied. The protected children have a significantly lower concentration of serum gamma globulin than the unprotected children from the age of 12 months onwards. In children, sicklers have a significantly higher serum gamma globulin than non-sicklers. It is suggested that sickling protects against malaria by enhancing the antibody response against the malaria parasite.

Entities: Disease Species

Keywords: ANEMIA, SICKLE CELL/immunology; MALARIA/immunology

Mesh：

Substances：
gamma-Globulins

Year: 1960 PMID： 13819366 PMCID： PMC480019 DOI： 10.1136/jcp.13.2.118

Source DB: PubMed Journal: J Clin Pathol ISSN： 0021-9746 Impact factor: 3.411

16 in total

1. Racial variation in serum globulins.

Authors: P COMENS
Journal: Am J Med Sci Date: 1957-03 Impact factor: 2.378

2. Serum protein changes induced by Plasmodium berghei infection in rats and Plasmodium knowlesi infection in monkeys.

Authors: A W WOODRUFF
Journal: Trans R Soc Trop Med Hyg Date: 1957-09 Impact factor: 2.184

3. The serum proteins of healthy adult Nigerians.

Authors: J C EDOZIEN
Journal: J Clin Pathol Date: 1957-08 Impact factor: 3.411

4. The serum proteins of aborigines in the Warburton Range area.

Authors: D H CURNOW
Journal: Med J Aust Date: 1957-10-26 Impact factor: 7.738

5. Serum protein concentrations in the North American Negroid.

Authors: H M RAWNSLEY; V L YONAN; J G REINHOLD
Journal: Science Date: 1956-06-01 Impact factor: 47.728

6. Distribution of parasites in the red cells of sickle-cell trait carriers infected with Plasmodium falciparum.

Authors: M J MILLER; J V NEEL; F B LIVINGSTONE
Journal: Trans R Soc Trop Med Hyg Date: 1956-05 Impact factor: 2.184

7. A note on the distribution of the serum protein fractions in apparently normal persons in Caracas.

Authors: J VERA; M ROCHE
Journal: J Lab Clin Med Date: 1956-03

8. Some aspects of the serum protein pattern of Africans.

Authors: L ARENS; J F BROCK
Journal: S Afr J Clin Sci Date: 1954-01

9. Protection afforded by sickle-cell trait against subtertian malareal infection.

Authors: A C ALLISON
Journal: Br Med J Date: 1954-02-06

10. Effects of heavy and repeated malarial infections on Gambian infants and children; effects of erythrocytic parasitization.

Authors: I A MCGREGOR; H M GILLES; J H WALTERS; A H DAVIES; F A PEARSON
Journal: Br Med J Date: 1956-09-22

12 in total

1. MALARIAL ANTIBODY TITRES OF WEST AFRICANS IN BRITAIN.

Authors: S F KUVIN; A VOLLER
Journal: Br Med J Date: 1963-08-24

2. Serum protein profile in sickle cell disease.

Authors: U P Isichei
Journal: J Clin Pathol Date: 1979-02 Impact factor: 3.411

3. Polyarthritis in Western Nigeria. I. Rheumatoid arthritis.

Authors: B M Greenwood
Journal: Ann Rheum Dis Date: 1969-09 Impact factor: 19.103

4. Hemoglobin S and C heterozygosity enhances neither the magnitude nor breadth of antibody responses to a diverse array of Plasmodium falciparum antigens.

Authors: Xiaolin Tan; Boubacar Traore; Kassoum Kayentao; Aissata Ongoiba; Safiatou Doumbo; Michael Waisberg; Ogobara K Doumbo; Philip L Felgner; Rick M Fairhurst; Peter D Crompton
Journal: J Infect Dis Date: 2011-10-12 Impact factor: 5.226

5. Platelet function, factor VIII, fibrinogen, and fibrinolysis in Nigerians and Europeans in relation to atheroma and thrombosis.

Authors: E Dupuy; A F Fleming; J P Caen
Journal: J Clin Pathol Date: 1978-11 Impact factor: 3.411