| Literature DB >> 1381480 |
Abstract
The genotoxicity of the rodent carcinogen 2,4,6-trichlorophenol (TCP) was studied without exogenous metabolic activation in V79 Chinese hamster cells. TCP did not induce mutation at the hprt locus to 6-thioguanine resistance or structural chromosome aberrations. However, it produced statistically significant, dose-related increases in hyperdiploidy and micronuclei. From these results it appears that TCP causes chromosome malsegregation as its major mode of genotoxic action.Entities:
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Year: 1992 PMID： 1381480 DOI： 10.1016/0165-1218(92)90046-3
Source DB: PubMed Journal: Mutat Res ISSN： 0027-5107 Impact factor: 2.433