Action of two ethyl thiol esters against experimental tuberculosis in the guinea-pig.

Two thiol esters, ethyl dithiolterephthalate (Compound 13,130) and ditophal (ethyl dithiolisophthalate; Etisul), have been tested for their antituberculosis activity in guinea-pigs. Compound 13,130 was active at a dose of 100 mg./Kg. twice daily by mouth in animals infected subcutaneously, but was inactive against an intracerebral infection at 50 mg./kg. Ditophal was active in the subcutaneously infected animals at 200 mg./kg. orally or 50 mg./kg. subcutaneously. Higher doses subcutaneously were irritant.