Literature DB >> 1381304

Expression of CD56 (NKH-1) differentiation antigen in human thyroid epithelium.

J Zeromski1, M Bagnasco, F Paolieri, G Dworacki.   

Abstract

Leu-19 (CD56) MoAb is well known to recognize gp220 expressed on natural killer (NK) cells and is widely used as a NK cell marker. The expression of CD56 antigen was tested by means of sensitive alkaline phosphatase-anti-alkaline phosphatase (APAAP) immunohistochemical technique and the above mentioned MoAb as a primary antibody, on frozen sections of various fresh human tissues. Out of 11 organs examined only thyroid gland provided a distinct reaction confined to cell membranes of epithelial follicular cells. The reaction had a diffuse pattern in cases of Graves' disease and colloidal goitre while in Hashimoto's thyroiditis presented as a focal pattern. Other anti-NK cell MoAbs such as VD4 (CD16) and Leu-7 (CD57) reacted only with single cells of thyroid stroma. The results of APAAP staining were confirmed by the cytofluorimetric assessment of isolated thyroid cells. It is speculated that CD56 expression on thyroid cells may have a functional significance, perhaps related to neural-endocrine interactions.

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Year:  1992        PMID： 1381304      PMCID： PMC1554472          DOI： 10.1111/j.1365-2249.1992.tb06983.x

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  16 in total

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Journal:  Eur J Immunol       Date:  1986-09       Impact factor: 5.532

2.  CD16 surface molecules regulate the cytolytic function of CD3CD16+ human natural killer cells.

Authors:  A Moretta; G Tambussi; E Ciccone; D Pende; G Melioli; L Moretta
Journal:  Int J Cancer       Date:  1989-10-15       Impact factor: 7.396

3.  Expression of intercellular adhesion molecule-1 (ICAM-1) on thyroid epithelial cells in Hashimoto's thyroiditis but not in Graves' disease or papillary thyroid cancer.

Authors:  M Bagnasco; A Caretto; D Olive; B Pedini; G W Canonica; C Betterle
Journal:  Clin Exp Immunol       Date:  1991-02       Impact factor: 4.330

4.  Expression of an intercellular adhesion molecule, ICAM-1, by human thyroid cells.

Authors:  A P Weetman; S Cohen; M W Makgoba; L K Borysiewicz
Journal:  J Endocrinol       Date:  1989-07       Impact factor: 4.286

5.  Neural cell adhesion molecule (NCAM) is the antigen recognized by monoclonal antibodies of similar specificity in small-cell lung carcinoma and neuroblastoma.

Authors:  K Patel; S E Moore; G Dickson; R J Rossell; P C Beverley; J T Kemshead; F S Walsh
Journal:  Int J Cancer       Date:  1989-10-15       Impact factor: 7.396

6.  Autoimmune thyroid disease: purification and phenotypic analysis of intrathyroid T cells.

Authors:  G W Canonica; M Caria; G Torre; A Risso; M E Cosulich; M Bagnasco
Journal:  J Endocrinol Invest       Date:  1984-12       Impact factor: 4.256

7.  Expression of markers shared between human natural killer cells and neuroblastoma lines.

Authors:  R C McGarry; A Pinto; D R Hammersley-Straw; C L Trevenen
Journal:  Cancer Immunol Immunother       Date:  1988       Impact factor: 6.968

8.  Involvement of CD56 (NKH-1/Leu-19 antigen) as an adhesion molecule in natural killer-target cell interaction.

Authors:  T Nitta; H Yagita; K Sato; K Okumura
Journal:  J Exp Med       Date:  1989-11-01       Impact factor: 14.307

9.  Identity of Leu-19 (CD56) leukocyte differentiation antigen and neural cell adhesion molecule.

Authors:  L L Lanier; R Testi; J Bindl; J H Phillips
Journal:  J Exp Med       Date:  1989-06-01       Impact factor: 14.307

10.  Identification of four subsets of human CD3-CD16+ natural killer (NK) cells by the expression of clonally distributed functional surface molecules: correlation between subset assignment of NK clones and ability to mediate specific alloantigen recognition.

Authors:  A Moretta; C Bottino; D Pende; G Tripodi; G Tambussi; O Viale; A Orengo; M Barbaresi; A Merli; E Ciccone
Journal:  J Exp Med       Date:  1990-12-01       Impact factor: 14.307
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  6 in total

1.  Diagnostic utility of immunohistochemical panel in various thyroid pathologies.

Authors:  Arturs Ozolins; Zenons Narbuts; Ilze Strumfa; Guna Volanska; Janis Gardovskis
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2.  Characterization of neural cell adhesion molecule (NCAM) expression in thyroid follicular cells: induction by cytokines and over-expression in autoimmune glands.

Authors:  F Vargas; E Tolosa; M Sospedra; M Catálfamo; A Lucas-Martín; G Obiols; R Pujol-Borrell
Journal:  Clin Exp Immunol       Date:  1994-12       Impact factor: 4.330

3.  The Role of CD56 in Thyroid Fine Needle Aspiration Cytology: A Pilot Study Performed on Liquid Based Cytology.

Authors:  Tommaso Bizzarro; Maurizio Martini; Carla Marrocco; Donato D'Amato; Emanuela Traini; Celestino Pio Lombardi; Alfredo Pontecorvi; Guido Fadda; Luigi Maria Larocca; Esther Diana Rossi
Journal:  PLoS One       Date:  2015-07-17       Impact factor: 3.240

4.  Diagnostic importance of CD56 with fine-needle aspiration cytology in suspected papillary thyroid carcinoma cases.

Authors:  Ozgen Arslan Solmaz
Journal:  Cytojournal       Date:  2018-01-25       Impact factor: 2.091

5.  The Usefulness of Immunocytochemistry of CD56 in Determining Malignancy from Indeterminate Thyroid Fine-Needle Aspiration Cytology.

Authors:  Hyunseo Cha; Ju Yeon Pyo; Soon Won Hong
Journal:  J Pathol Transl Med       Date:  2018-10-15

6.  Absent CD56 expression in papillary thyroid carcinoma: A finding of potential diagnostic value in problematic cases of thyroid pathology.

Authors:  Mozhgan Mokhtari; Mehdi Eftekhari; Reza Tahririan
Journal:  J Res Med Sci       Date:  2013-12       Impact factor: 1.852
  6 in total

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