Literature DB >> 13811550

Induced synthesis of liver microsomal enzymes which metabolize foreign compounds.

A H CONNEY, J R GILLETTE, J K INSCOE, E R TRAMS, H S POSNER.   

Abstract

The administration of 3,4-benzpyrene to rats markedly increases the activities of certain liver microsomal enzymes which metabolize foreign compounds. Evidence based on studies of enzyme induction is presented which suggests the presence in liver microsomes of several enzymes which can catalyze the same type of reaction.

Entities:  

Keywords:  ENZYMES; LIVER

Mesh：

Substances：

Year:  1959        PMID： 13811550     DOI： 10.1126/science.130.3387.1478

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  15 in total

1.  METHYLCHOLANTHRENE-INDUCED CHANGES IN RAT LIVER NUCLEAR RNA.

Authors:  L A LOEB; H V GELBOIN
Journal:  Proc Natl Acad Sci U S A       Date:  1964-11       Impact factor: 11.205

2.  The biological disposition of morphine and its surrogates. 3.

Authors:  E L WAY; T K ADLER
Journal:  Bull World Health Organ       Date:  1962       Impact factor: 9.408

3.  Vascular permeability in experimental kernicterus: an electron-microscopic study of the blood-brain barrier.

Authors:  H C Chen; C S Lin; I N Lien
Journal:  Am J Pathol       Date:  1967-07       Impact factor: 4.307

4.  [Carboxylesterases of the microsome fraction. Hydrolysis of tributyrin, procaine and phenacetin by some organs and liver microsomes of various animal species].

Authors:  H C Benöhr; W Franz; K Krisch
Journal:  Naunyn Schmiedebergs Arch Pharmakol Exp Pathol       Date:  1966

5.  [The oxidative N-demethylation of N-monomethyl-p-nitroaniline].

Authors:  K J Netter
Journal:  Naunyn Schmiedebergs Arch Pharmakol Exp Pathol       Date:  1966

6.  Inhibition of mouse skin tumorigenesis by actinomycin D.

Authors:  H V Gelboin; M Klein; R R Bates
Journal:  Proc Natl Acad Sci U S A       Date:  1965-06       Impact factor: 11.205

7.  Drug induction of hepatic glutathione S-transferases in male and female rats*.

Authors:  N Kaplowitz; J Kuhlekamp; G Clifton
Journal:  Biochem J       Date:  1975-02       Impact factor: 3.857

8.  Effect of two isomeric tetrachlorobiphenyls on rats and their hepatic enzymes.

Authors:  P R Chen; H M Mehendale; L Fishbein
Journal:  Arch Environ Contam Toxicol       Date:  1973-02       Impact factor: 2.804

9.  [Influence of extracts from air-borne dust and of some polyaromatic hydrocarbons on the benzo(a)pyren breakdown by microsomal enzymes from rat liver in vitro].

Authors:  R Tomingas; W Dehnen
Journal:  Z Krebsforsch       Date:  1970

10.  [Dependance on age and sex of benzo(a)pyren metabolism in vitro by microsomal enzymes from rat liver].

Authors:  W Dehnen; R Tomingas; H Schagholi
Journal:  Z Krebsforsch       Date:  1970-03-10
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