Literature DB >> 1380876

Protection of rat hippocampus against ischemic neuronal damage by pretreatment with sublethal ischemia.

Y Liu1, H Kato, N Nakata, K Kogure.   

Abstract

We examined whether preconditioning with sublethal ischemia protects against neuronal damage following subsequent lethal ischemic insults. Forebrain ischemia for 3 min in Wistar rats increased heat shock protein-70 immunoreactivity in the hippocampal CA1 subfield but produced no neuronal damage. Preconditioning with 3 min of ischemia followed by 3 days of reperfusion protected against hippocampal CA1 neuronal damage following 6 and 8 min of ischemia but not damage after 10 min of ischemia. The result strongly suggests that stress response induced by sublethal ischemia protects against ischemic brain damage.

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Year:  1992        PMID: 1380876     DOI: 10.1016/0006-8993(92)91380-w

Source DB:  PubMed          Journal:  Brain Res        ISSN: 0006-8993            Impact factor:   3.252


  36 in total

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