Literature DB >> 13803718

A comparative study of the effects of drugs on the arousal system of the brain.

P B BRADLEY, B J KEY.   

Abstract

The effects of twelve drugs, eleven of which are reported to be tranquillizers, have been studied in relation to thresholds for arousal produced both by direct stimulation of the brain stem reticular formation and also by afferent nerve stimulation. The drugs can be grouped according to whether (a) like chlorpromazine they produce a slight rise in thresholds for brain stem stimulation and block sensory-induced arousal, (b) cause dissociation between behaviour and electrical activity of the brain, (c) have no effects on thresholds for brain stem stimulation and only slight effects on afferent nerve-induced arousal or (d) have no effect on arousal responses at all.

Entities:  

Keywords:  BRAIN/pharmacology; TRANQUILIZING AGENTS/pharmacology

Mesh：

Substances：

Year:  1959        PMID： 13803718      PMCID： PMC1481747          DOI： 10.1111/j.1476-5381.1959.tb00254.x

Source DB:  PubMed          Journal:  Br J Pharmacol Chemother        ISSN： 0366-0826


  18 in total

1.  Neuropharmacological aspects of reserpine.

Authors:  J A SCHNEIDER; A J PLUMMER; A E EARL; R GAUNT
Journal:  Ann N Y Acad Sci       Date:  1955-04-15       Impact factor: 5.691

2.  The treatment of depressive conditions with imipramine (G 22355).

Authors:  H E LEHMANN; C H CAHN; R L DE VERTEUIL
Journal:  Can Psychiatr Assoc J       Date:  1958-10

3.  [New series of neuroplegic compounds derived from phenothiazine].

Authors:  J SCHMITT; J MERCIER; M AUROUSSEAU; A HALLOT; P COMOY
Journal:  C R Hebd Seances Acad Sci       Date:  1957-01-07

4.  The effect of chlorpromazine and methopromazine on the electrical activity of the brain in the cat.

Authors:  P B BRADLEY; A J HANCE
Journal:  Electroencephalogr Clin Neurophysiol       Date:  1957-05

5.  Evidence for the participation of serotonin in mental processes.

Authors:  D W WOOLLEY; E N SHAW
Journal:  Ann N Y Acad Sci       Date:  1957-03-14       Impact factor: 5.691

6.  The use of frenquel in the treatment of disturbed patients with psychoses of long duration.

Authors:  F RINALDI; L H RUDY; H E HIMWICH
Journal:  Am J Psychiatry       Date:  1955-11       Impact factor: 18.112

7.  Effects of hallucinogenic and tranquilizing drugs on serotonin evoked uterine contractions.

Authors:  E COSTA
Journal:  Proc Soc Exp Biol Med       Date:  1956-01

8.  [Effects of chloropromazine on central nervous system].

Authors:  G HIEBEL; M BONVALLET; P DELL
Journal:  Sem Hop       Date:  1954-06-06

9.  [Electroencephalographic study of the central action of largactil (4560 RP)].

Authors:  H TERZIAN
Journal:  Rass Neurol Veg       Date:  1952-04

10.  The pharmacological properties of 2-methyl-2-n-propyl-1,3-propanediol dicarbamate (miltown), a new interneuronal blocking agent.

Authors:  F M BERGER
Journal:  J Pharmacol Exp Ther       Date:  1954-12       Impact factor: 4.030
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  8 in total

1.  EFFECTS OF BENACTYZINE AND ADIPHENINE ON INSTRUMENTAL AVOIDANCE CONDITIONING IN A SHUTTLE-BOX.

Authors:  G BIGNAMI
Journal:  Psychopharmacologia       Date:  1964-03-11

2.  A case of anorexia nervosa in a male.

Authors:  A H CRISP; F J ROBERTS
Journal:  Postgrad Med J       Date:  1962-06       Impact factor: 2.401

3.  The comparative pharmacology of some psychotropic drugs.

Authors:  E JACOBSEN
Journal:  Bull World Health Organ       Date:  1959       Impact factor: 9.408

4.  Supraspinal interactions of anesthetic, neuroleptic and analeptic drugs on the fusimotor effects of pinna stimulation in the cat.

Authors:  E D Schomburg
Journal:  Exp Brain Res       Date:  1970       Impact factor: 1.972

5.  [Changes in habituation of the alpha rhythm arrest reaction in humans under the effect of chlorpromazine and haloperidol].

Authors:  R Tissot; J Bovet
Journal:  Psychopharmacologia       Date:  1967

6.  Asymmetrical cross-tolerance between morphine and scopolamine induced antinociception in the primate: differential sites of action.

Authors:  A Pert; G Maxey
Journal:  Psychopharmacologia       Date:  1975-10-31

7.  The effect of iproniazid and imipramine on the blood platelet 5-hydroxytrptamine level in man.

Authors:  E F MARSHALL; G S STIRLING; A C TAIT; A TODRICK
Journal:  Br J Pharmacol Chemother       Date:  1960-03

8.  Effect of thyrotropin-releasing hormone (TRH) and antidepressant agents on brain stem and hypothalamic multiple unit activity in the cat.

Authors:  L Korányi; V Tamásy; K Lissák; I Király; J Borsy
Journal:  Psychopharmacology (Berl)       Date:  1976-09-17       Impact factor: 4.530
  8 in total

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