Literature DB >> 13795316

Enzymatic O-methylation of N-acetylserotonin to melatonin.

J AXELROD, H WEISSBACH.   

Abstract

An enzyme, hydroxyindole-O-methyl transferase, that can transfer the methyl group of S-adenosylmethionine to the hydroxy group of N-acetylserotonin to form the hormone melatonin is described. This enzyme, which is highly localized in the pineal gland, also O-methylates serotonin.

Entities:  

Keywords:  METHIONINE/related compounds; SEROTONIN/related compounds; TRANSFERASES/metabolism

Mesh：

Substances：

Year:  1960        PMID： 13795316     DOI： 10.1126/science.131.3409.1312

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  59 in total

1.  Fine structural changes in the hamster pineal gland after blinding and superior cervical ganglionectomy.

Authors:  H S Lin; B H Hwang; C Y Tseng
Journal:  Cell Tissue Res       Date:  1975       Impact factor: 5.249

2.  EFFECT OF MELATONIN ON SPONTANEOUS CONTRACTIONS AND RESPONSE TO 5-HYDROXYTRYPTAMINE OF RAT ISOLATED DUODENUM.

Authors:  M R QUASTEL; R RAHAMIMOFF
Journal:  Br J Pharmacol Chemother       Date:  1965-04

Review 3.  A review of the multiple actions of melatonin on the immune system.

Authors:  Antonio Carrillo-Vico; Juan M Guerrero; Patricia J Lardone; Russel J Reiter
Journal:  Endocrine       Date:  2005-07       Impact factor: 3.633

Review 4.  The isolation of the vitamin B12 coenzyme and the role of the vitamin in methionine synthesis.

Authors:  Herbert Weissbach
Journal:  J Biol Chem       Date:  2008-06-04       Impact factor: 5.157

5.  A physiologically based mathematical model of melatonin including ocular light suppression and interactions with the circadian pacemaker.

Authors:  Melissa A St Hilaire; Claude Gronfier; Jamie M Zeitzer; Elizabeth B Klerman
Journal:  J Pineal Res       Date:  2007-10       Impact factor: 13.007

Review 6.  Melatonin biosynthesis in the mammalian pineal gland.

Authors:  D Sugden
Journal:  Experientia       Date:  1989-10-15

7.  Electron microscopic study of an ectopic pinealoma.

Authors:  K Misugi; L Liss; E J Bradel
Journal:  Acta Neuropathol       Date:  1967-11-29       Impact factor: 17.088

8.  Day and night rhythms in the methylation of N-acetylserotonin/5-hydroxytryptophol in the pineal gland of males rats of different ages.

Authors:  M G Balemans; W C Legerstee; J van Benthem
Journal:  J Neural Transm       Date:  1979       Impact factor: 3.575

9.  Nucleotide sequence of the tcmII-tcmIV region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens and evidence that the tcmN gene encodes a multifunctional cyclase-dehydratase-O-methyl transferase.

Authors:  R G Summers; E Wendt-Pienkowski; H Motamedi; C R Hutchinson
Journal:  J Bacteriol       Date:  1992-03       Impact factor: 3.490

10.  Melatonin receptor expression in Xenopus laevis surface corneal epithelium: diurnal rhythm of lateral membrane localization.

Authors:  Allan F Wiechmann; Lindsey R Hollaway; Jody A Summers Rada
Journal:  Mol Vis       Date:  2009-11-17       Impact factor: 2.367
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