Literature DB >> 1379431

T cell receptor V beta repertoire of double-negative alpha/beta T cells in patients with systemic sclerosis.

A Sakamoto1, T Sumida, T Maeda, M Itoh, T Asai, H Takahashi, S Yoshida, T Koike, H Tomioka, S Yoshida.   

Abstract

OBJECTIVE: To analyze the T cell receptor V beta gene on double-negative (DN) alpha/beta T cells, which are increased in number, on peripheral blood lymphocytes (PBL) from patients with systemic sclerosis (SSc).
METHODS: The DN alpha/beta T cells were sorted by flow cytometry from PBL obtained from 3 patients with SSc. The V beta repertoire was analyzed by polymerase chain reaction.
RESULTS: Only 1 or 2 V beta genes (V beta 5/7, 5, or 17) were predominantly expressed on DN alpha/beta T cells from these 3 patients.
CONCLUSION: The V beta repertoire on DN alpha/beta T cells in PBL from patients with SSc is rather restricted.

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Year:  1992        PMID： 1379431     DOI： 10.1002/art.1780350815

Source DB:  PubMed          Journal:  Arthritis Rheum        ISSN： 0004-3591


  9 in total

1.  Peripheral T lymphocytes from patients with early systemic sclerosis co-cultured with autologous fibroblasts undergo an oligoclonal expansion similar to that occurring in the skin.

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Review 2.  A Mechanistic Insight into the Pathogenic Role of Interleukin 17A in Systemic Autoimmune Diseases.

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3.  Human T-cell receptor (TCR) alpha/beta + CD4-CD8- T cells express oligoclonal TCRs, share junctional motifs across TCR V beta-gene families, and phenotypically resemble memory T cells.

Authors:  E G Brooks; S P Balk; K Aupeix; M Colonna; J L Strominger; V Groh-Spies
Journal:  Proc Natl Acad Sci U S A       Date:  1993-12-15       Impact factor: 11.205

4.  Increased frequency of in vivo hprt gene-mutated T cells in the peripheral blood of patients with systemic sclerosis.

Authors:  P P Sfikakis; J Tesar; S Theocharis; G L Klipple; G C Tsokos
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5.  Human alpha beta T-cell receptor CD4-CD8 T-cell clones are predominantly Th0-like.

Authors:  P D Katsikis; S B Cohen; J G Murison; J Uren; L M Hibbart; R E Callard; F Di Padova; M Feldmann; M Londei
Journal:  Immunology       Date:  1995-04       Impact factor: 7.397

6.  IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cells.

Authors:  Jonathan P Sherlock; Barbara Joyce-Shaikh; Scott P Turner; Cheng-Chi Chao; Manjiri Sathe; Jeff Grein; Daniel M Gorman; Edward P Bowman; Terrill K McClanahan; Jennifer H Yearley; Gérard Eberl; Christopher D Buckley; Robert A Kastelein; Robert H Pierce; Drake M Laface; Daniel J Cua
Journal:  Nat Med       Date:  2012-07-01       Impact factor: 53.440

7.  A pathway of costimulation that prevents anergy in CD28- T cells: B7-independent costimulation of CD1-restricted T cells.

Authors:  S M Behar; S A Porcelli; E M Beckman; M B Brenner
Journal:  J Exp Med       Date:  1995-12-01       Impact factor: 14.307

8.  Selective reduction of T cells bearing invariant V alpha 24J alpha Q antigen receptor in patients with systemic sclerosis.

Authors:  T Sumida; A Sakamoto; H Murata; Y Makino; H Takahashi; S Yoshida; K Nishioka; I Iwamoto; M Taniguchi
Journal:  J Exp Med       Date:  1995-10-01       Impact factor: 14.307

9.  Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha/beta T cells demonstrates preferential use of several V beta genes and an invariant TCR alpha chain.

Authors:  S Porcelli; C E Yockey; M B Brenner; S P Balk
Journal:  J Exp Med       Date:  1993-07-01       Impact factor: 14.307
  9 in total

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