Literature DB >> 13792172

Mechanism of action of oral antidiabetic drugs.

R AIMAN, N CHAUDHARY.   

Abstract

The fall in blood sugar with carbutamide (BZ55) 24 hr. after the maintenance dose of insulin (28.1%+/-2.9 s.e) in rabbits made severely diabetic with alloxan was significantly different from the change in the blood sugar with the same drug given 72 hr. (6.8%+/-2.0) or distilled water given 24 hr. (7.7%+/-1.3) respectively after the last dose of insulin. It is postulated that the drug acts by liberating bound insulin in the plasma.

Entities:  

Keywords:  CARBUTAMIDE/pharmacology

Mesh：

Substances：

Year:  1959        PMID： 13792172      PMCID： PMC1481738          DOI： 10.1111/j.1476-5381.1959.tb00261.x

Source DB:  PubMed          Journal:  Br J Pharmacol Chemother        ISSN： 0366-0826


  8 in total

1.  Insulin in protein fractions of serum from healthy people and from insulin-treated diabetics.

Authors:  P J RANDLE; K W TAYLOR
Journal:  Lancet       Date:  1958-11-08       Impact factor: 79.321

2.  Long-term studies of the sulfonylureas in totally depancreatized dogs.

Authors:  H T RICKETTS; H L WILDBERGER; H SCHMID
Journal:  Ann N Y Acad Sci       Date:  1957-07-10       Impact factor: 5.691

3.  The effect of human plasma on the glucose uptake of the rat diaphragm before and after administration of carbutamide.

Authors:  R AIMAN; R D KULKARNI
Journal:  Br J Pharmacol Chemother       Date:  1957-12

4.  Insulin secretion following carbutamide injections in normal dogs.

Authors:  P P FOA; G GALANSINO; G POZZA
Journal:  Proc Soc Exp Biol Med       Date:  1956-12

5.  Insulin I-131 metabolism in man; plasma-binding, distribution and degradation.

Authors:  R W COX; E D HENLEY; G W WELSH; R H WILLIAMS
Journal:  Am J Med       Date:  1956-09       Impact factor: 4.965

6.  Anterior pituitary growth hormone and blood sugar levels of normal and diabetic dogs.

Authors:  O V SIREK; C H BEST
Journal:  Am J Physiol       Date:  1956-06

7.  Insulin distribution and degradation.

Authors:  R H WILLIAMS
Journal:  Metabolism       Date:  1956-03       Impact factor: 8.694

8.  The effect of serum from insulin-resistant cases on the combination of insulin with the rat diaphragm.

Authors:  J B MARSH; N HAUGAARD
Journal:  J Clin Invest       Date:  1952-01       Impact factor: 14.808
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.