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Literature DB >> 13790762

The development of antibodies to penicilin in rabbits.

Abstract

A method for the production of antibodies specifically directed against penicillin is described. The inability of this antibody to significantly reduce the antibiotic activity of penicillin is noted. Evidence to show the variability of specificities of various sera, some directed for the most part against the side chain, others against the nucleus is presented. Studies on serum fractions separated electrophorectically indicate that the antibody migrates in the fast gamma-globulin and beta-globulin fractions and requires dextran or albumin to effect agglutination. The inability of penicilloic acid, an hydrolysis product of penicillin to provoke antibody formation despite its ability to inhibit the antibody is shown and the implications of this observations are discussed.

Entities: Chemical Species

Keywords: ANTIEMETICS/experimental; PENICILLIN/toxicology

Mesh：

Substances：

Year: 1960 PMID： 13790762 PMCID： PMC2137283 DOI： 10.1084/jem.111.5.611

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

10 in total

1. On modification of penicillin antigenicity.

Authors: G H BERRYMAN; E W FISHERMAN
Journal: J Allergy Date: 1959 Jul-Aug

2. Penicillin as an antigen.

Authors: K C WATSON; S M JOUBERT; M A BENNETT
Journal: Nature Date: 1959-02-14 Impact factor: 49.962

3. Circulating antibody directed against penicillin.

Authors: A B LEY; J P HARRIS; M BRINKLEY; B LILES; J A JACK; A CAHAN
Journal: Science Date: 1958-05-09 Impact factor: 47.728

4. Studies of hypersensitivity to low molecular weight substances. III. The 2,4-dinitrophenyl group as a determinant in the preciptin reaction.

Authors: H N EISEN; M E CARSTEN; S BELMAN
Journal: J Immunol Date: 1954-11 Impact factor: 5.422

5. Penicillin reactions; their nature, growing importance, recognition, management and prevention.

Authors: R A KERN; N A WIMBERLEY
Journal: Am J Med Sci Date: 1953-10 Impact factor: 2.378

6. The Relation of Protein Binding to the Pharmacology and Antibacterial Activity of Penicillins X, G, Dihydro F, and K.

Authors: R Tompsett; S Shultz; W McDermott
Journal: J Bacteriol Date: 1947-05 Impact factor: 3.490

7. Zone electrophoresis.

Authors: H G KUNKEL
Journal: Methods Biochem Anal Date: 1954

8. Elicitation of delayed allergic skin reactions with haptens; the dependence of elicitation on hapten combination with protein.

Authors: H N EISEN; L ORRIS; S BELMAN
Journal: J Exp Med Date: 1952-05-01 Impact factor: 14.307

9. STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS.

Authors: K Landsteiner; J Jacobs
Journal: J Exp Med Date: 1935-04-30 Impact factor: 14.307

10. STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS : VIII. SENSITIZATION TO PICRIC ACID; SUBSIDIARY AGENTS AND MODE OF SENSITIZATION.

Authors: K Landsteiner; A A Di Somma
Journal: J Exp Med Date: 1940-09-30 Impact factor: 14.307

10 in total

5 in total

4. Studies on the mechanism of the formation of the penicillin antigen. III. The N-(D-alpha-benzylpenicilloyl) group as an antigenic determinant responsible for hypersensitivity to penicillin G.

Authors: B B LEVINE; Z OVARY
Journal: J Exp Med Date: 1961-12-01 Impact factor: 14.307

5. Study of penicillin antibodies by fluorescence polarization and immunodiffusion.

Authors: W B Dandliker; S P Halbert; M C Florin; R Alonso; H C Schapiro
Journal: J Exp Med Date: 1965-12-01 Impact factor: 14.307