Literature DB >> 13787219

Polynuclear aromatic hydrocarbons, steroids and carcinogenesis.

N C YANG, A J CASTRO, M LEWIS, T W WONG.   

Abstract

In addition to the electronic factors, there is a steric factor responsible for the carcinogenicity of polynuclear aromatic hydrocarbons. A carcinogenic polynuclear aromatic hydrocarbon must bear steric resemblance to steroids. One possible implication to this requirement for carcinogenicity is that these hydrocarbons may act on the same sites as steroid hormones.

Entities:  

Keywords:  HYDROCARBONS/chemistry; NEOPLASMS/experimental; STEROIDS/chemistry

Mesh：

Substances：

Year:  1961        PMID： 13787219     DOI： 10.1126/science.134.3476.386

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  8 in total

1.  DISTRIBUTION AND SPECIES LIMITATION OF THE ADRENAL LESIONS INDUCED BY 7,12-DIMETHYLBENZ(A)ANTHRACENE.

Authors:  F CEFIS; C M GOODALL
Journal:  Am J Pathol       Date:  1965-02       Impact factor: 4.307

2.  [On the relation between steroids and carcinogenic compounds. III. 2-Amino- and 3-amino-4-methyl-Delta1, 3,5(10)-estratrien-17beta-o1].

Authors:  H DANNENBERG
Journal:  Z Krebsforsch       Date:  1963

3.  Geometry of carcinogenic polycyclic aromatic hydrocarbons.

Authors:  C B Huggins; J Pataki; R G Harvey
Journal:  Proc Natl Acad Sci U S A       Date:  1967-12       Impact factor: 11.205

4.  Epigenetics meets endocrinology.

Authors:  Xiang Zhang; Shuk-Mei Ho
Journal:  J Mol Endocrinol       Date:  2011-02       Impact factor: 5.098

5.  INDUCED PROTECTION OF ADRENAL CORTEX AGAINST 7,12-DIMETHYLBENZ(ALPHA)ANTHRACENE. INFLUENCE OF ETHIONINE. INDUCTION OF MENADIONE REDUCTASE. INCORPORATION OF THYMIDINE-H3.

Authors:  C HUGGINS; R FUKUNISHI
Journal:  J Exp Med       Date:  1964-01-01       Impact factor: 14.307

6.  Selective adrenal necrosis and apoplexy induced by 7, 12-dimethylbenz(a)anthracene.

Authors:  C HUGGINS; S MORII
Journal:  J Exp Med       Date:  1961-11-01       Impact factor: 14.307

7.  The carcinogenicity of 15,16-dihydro-11-methyl-cyclopenta[a]phenanthren-17-one.

Authors:  M M Coombs; T S Bhatt; S Young
Journal:  Br J Cancer       Date:  1979-12       Impact factor: 7.640

8.  A new model for inducing malignant ovarian tumours in rats.

Authors:  J Hilfrich
Journal:  Br J Cancer       Date:  1973-07       Impact factor: 7.640
  8 in total

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