The physiology of GABAB receptors in the vertebrate retina.

Writing a chapter on retinal GABAB receptors is premature, as evidenced by the paucity of citations more than two years old. Despite that, this area of retinal pharmacology has made significant strides and, although it is a story without an ending, it has had an exciting beginning. To date, the experiments indicate that horizontal cell feedback to cones is mediated, at least in part, by the GABAB receptor system which probably regulates a potassium conductance. In the inner retina, GABAB receptors are found on bipolar cells, amacrines, and ganglion cells. Here, the actions are a subtle regulation of channel conductance, but the effects are a dramatic reorganization of a fundamental coding property of the retina, namely the distinction between tonic and phasic responses to light. In both the distal and proximal retina, the GABAB receptor does not appear to work alone, but instead works in concert with the GABAA receptor. The full significance of these interactions has yet to be determined. Although the discovery of the GABAB receptor has led to the resolution of several retinal mysteries, the case is far from closed. At this juncture, what can be said is that the GABAB receptor represents a unique and ubiquitous system that reveals the power of regulating calcium and potassium conductances, as opposed to the more familiar properties of the glutamate/acetylcholine regulated cationic conductances or the GABAA/glycine controlled chloride channels.