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Literature DB >> 13785397

Changes produced in mouse plasma proteins by acute bacterial infections.

Abstract

The immunoelectrophoretic patterns of plasma proteins from mice are altered significantly by acute infections. Some proteins are dissociated into two or more components, some showed striking increase in plasma concentration, others are depleted, and certain ones appear which are undetectable in normal samples. beta(1)-C dissociated into two electrophoretic components under a variety of conditions in addition to infections. Endotoxins and killed organisms in vivo, and specific precipitate absorption, heat and aging in vitro produced this change. Endotoxins injected into mice also induced a rise in haptoglobin though not as sharply or predictably as acute infection. Preliminary results with samples from hospital patients with acute diseases are discussed. It was concluded that study of experimental diseases in laboratory animals by these techniques could provide a fruitful basis for the investigation of the plasma protein changes in similar human diseases.

Entities: Disease Gene Species

Keywords: BLOOD PROTEINS/physiology; INFECTION/experimental

Mesh：

Substances：

Year: 1961 PMID： 13785397 PMCID： PMC2137463 DOI： 10.1084/jem.114.3.311

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

9 in total

1. [Electrophoresis on gelose and staining of the constituents].

Authors: J URIEL; J J SCHEIDEGGER
Journal: Bull Soc Chim Biol (Paris) Date: 1955

2. Adaptation of orbital bleeding technic to rapid serial blood studies.

Authors: V RILEY
Journal: Proc Soc Exp Biol Med Date: 1960 Aug-Sep

3. An immunologic and chemical study of the similarities between mouse and human serum proteins.

Authors: J CLAUSEN; J HEREMANS
Journal: J Immunol Date: 1960-02 Impact factor: 5.422

4. [Gamma-x-globulin, an immunoelectrophoretic demonstrable gamma-globulin-component with relations to C-reactive protein].

Authors: H E SCHULTZE; G SCHWICK; J SONNET; J HEREMANS; J L MICHAUX
Journal: Klin Wochenschr Date: 1960-01-15

5. [A micro-method of immuno-electrophoresis].

Authors: J J SCHEIDEGGER
Journal: Int Arch Allergy Appl Immunol Date: 1955

6. VARIATION IN PROTEIN AND POLYSACCHARIDE CONTENT OF SERA IN THE CHRONIC DISEASES, TUBERCULOSIS, SARCOIDOSIS, AND CARCINOMA.

Authors: F B Seibert; M V Seibert; A J Atno; H W Campbell
Journal: J Clin Invest Date: 1947-01 Impact factor: 14.808

7. RELATION OF A beta(1)-GLYCOPROTEIN OF HUMAN SERUM TO THE COMPLEMENT SYSTEM.

Authors: H J Müller-Eberhard; U Nilsson
Journal: J Exp Med Date: 1960-01-31 Impact factor: 14.307

8. The effect of the intestinal flora on the growth rate of mice, and on their susceptibility to experimental infections.

Authors: R J DUBOS; R W SCHAEDLER
Journal: J Exp Med Date: 1960-03-01 Impact factor: 14.307

9. Isolation and characterization of two beta1-glycoproteins of human serum.

Authors: H J MULLER-EBERHARD; U NILSSON; T ARONSSON
Journal: J Exp Med Date: 1960-02-01 Impact factor: 14.307

9 in total

14 in total

8. Normal serum cytotoxicity for P32-labeled smooth Enterobacteriaceae. 3. Isolation of a gammag normal antibody and characterization of other serum factors causing P32 loss.

Authors: J K Spitznagel
Journal: J Bacteriol Date: 1966-01 Impact factor: 3.490

9. Different allotypes of C3 degrade at different rates.

Authors: P H Kay; S Natsuume-Sakai; J Hayakawa; R L Dawkins
Journal: Immunogenetics Date: 1985 Impact factor: 2.846

10. A new acute phase protein elicited in mice by streptolysin O and other toxic or infectious agents.

Authors: R Rowen; M A Wiest
Journal: J Exp Med Date: 1965-09-01 Impact factor: 14.307

Changes produced in mouse plasma proteins by acute bacterial infections.

1. [Electrophoresis on gelose and staining of the constituents].

2. Adaptation of orbital bleeding technic to rapid serial blood studies.

3. An immunologic and chemical study of the similarities between mouse and human serum proteins.

4. [Gamma-x-globulin, an immunoelectrophoretic demonstrable gamma-globulin-component with relations to C-reactive protein].

5. [A micro-method of immuno-electrophoresis].

6. VARIATION IN PROTEIN AND POLYSACCHARIDE CONTENT OF SERA IN THE CHRONIC DISEASES, TUBERCULOSIS, SARCOIDOSIS, AND CARCINOMA.

7. RELATION OF A beta(1)-GLYCOPROTEIN OF HUMAN SERUM TO THE COMPLEMENT SYSTEM.

8. The effect of the intestinal flora on the growth rate of mice, and on their susceptibility to experimental infections.

9. Isolation and characterization of two beta1-glycoproteins of human serum.

1. CHARACTERIZATION OF A GENETICALLY IDENTIFIABLE COMPONENT OF COMPLEMENT IN MICE.

2. SYNTHESIS OF SERUM PROTEINS BY A CELL-FREE SYSTEM FROM RAT LIVER.

3. EFFECT OF BACTERIAL INFECTION ON THE SYNTHESIS OF SERUM PROTEINS BY A MOUSE LIVER CELL-FREE SYSTEM.

4. In vivo bactericidal activity of mouse complement against Escherichia coli.

5. Auto-reactivity to haemoglobin in the sera of cattle and sheep infected with haemolytic bacteria.

6. Isolation and study of murine C3.

7. Nitrogen metabolism and protein synthesis during pneumococcal sepsis in rats.

8. Normal serum cytotoxicity for P32-labeled smooth Enterobacteriaceae. 3. Isolation of a gammag normal antibody and characterization of other serum factors causing P32 loss.

9. Different allotypes of C3 degrade at different rates.

10. A new acute phase protein elicited in mice by streptolysin O and other toxic or infectious agents.