The genotoxicity of industrial wastes and effluents.

A review of the literature published on the genotoxicity of industrial wastes and effluents using short-term genetic bioassays is presented in this document. The importance of this task arises from the ubiquity of genotoxic compounds in the environment and the need to identify the sources of contamination so that efforts aimed at control and minimization can be implemented. Of even greater significance is the immediate concern for the welfare of human health and the environment. Subheadings of this document include a description of the genetic bioassays that have been used to test industrial wastes, a compendium of methods commonly used to prepare crude waste samples for bioassay, and a review of the genetic toxicity of wastes and effluents. Wastes and effluents have been grouped according to industrial source. Major categories include chemical and allied products, pulp and paper manufacturing, defense and munitions, petroleum refining, primary metal industries, and miscellaneous industrial manufacturers. Within each industrial category, a synopsis of individual genetic toxicity studies is presented, followed by an interpretation of results on a comprehensive, industry-wide basis. In this evaluation, a discussion of the types and extent of genotoxic damage caused by a particular set of wastes is presented, and potential sources of genotoxic activity are identified. Concluding the document is a commentary, which discloses potential shortcomings in the way in which current legislation protects human heath and the environment from the release of genotoxic substances via industrial wastes and effluents. It also provides an assessment of the genotoxic burden that industrial wastes place on the environment.