| Literature DB >> 1378426 |
E G Gibson1, H D Burns, H H Thorpe, W S Eng, R Ransom, H Solomon.
Abstract
Radioiodinated (+)-3-Iodo-MK-801 is a high affinity radioligand for the N-methyl-D-aspartate (NMDA) receptor-channel complex. We have demonstrated in vivo localization in the CNS of rat which is stereoselective and blocked by coinjection of unlabeled MK-801. Autoradiography indicates localization in vivo which is in concordance with in vitro autoradiographic studies. These results indicate that radioiodinated (+)-3-Iodo-MK-801 is a useful probe for in vitro and in vivo autoradiographic studies and suggest that radioligands for the NMDA receptor may be developed which will provide in vivo images of receptor distribution in man.Entities:
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Year: 1992 PMID： 1378426 DOI： 10.1016/0883-2897(92)90117-h
Source DB: PubMed Journal: Int J Rad Appl Instrum B ISSN： 0883-2897