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Literature DB >> 1378373

The safety of antidepressants.

Abstract

In this article, a distinction is proposed between safe and less safe antidepressants. The safety of 18 antidepressants is discussed in relation to 3 principal issues: the safety of the drug in the event of an overdose; the seriousness of its side effects; and the existence of dangerous interactions. On the basis of present information, it can be said with reasonable confidence that fluoxetine, fluvoxamine and paroxetine are safe antidepressants, and with some reservation (mainly because of hypnosedation) the same can be said of mianserin and trazodone.

Entities: Chemical Disease

Mesh：

Substances：
Antidepressive Agents

Year: 1992 PMID： 1378373 DOI： 10.2165/00003495-199200432-00007

Source DB: PubMed Journal: Drugs ISSN： 0012-6667 Impact factor: 9.546

35 in total

1. Do some antidepressants promote suicide?

Authors: S A Montgomery; R M Pinder
Journal: Psychopharmacology (Berl) Date: 1987 Impact factor: 4.530

2. A pharmacological profile of fluoxetine and other antidepressants on aspects of skilled performance and car handling ability.

Authors: I Hindmarch
Journal: Br J Psychiatry Suppl Date: 1988-09

3. Toxicity of antidepressants.

Authors: B E Leonard
Journal: Lancet Date: 1986-11-08 Impact factor: 79.321

Review 4. TCA poisoning treated in the intensive care unit.

Authors: B A Hultén
Journal: Pharmacopsychiatry Date: 1990-01 Impact factor: 5.788

5. Statistical predictions of suicide in depressives.

Authors: F Stallone; D L Dunner; J Ahearn; R R Fieve
Journal: Compr Psychiatry Date: 1980 Sep-Oct Impact factor: 3.735

6. Treatment of geriatric depression with trazodone, imipramine, and placebo: a double-blind study.

Authors: R Gerner; W Estabrook; J Steuer; L Jarvik
Journal: J Clin Psychiatry Date: 1980-06 Impact factor: 4.384

7. A comparative trial of fluoxetine and amitriptyline in patients with major depressive disorder.

Authors: J P Feighner
Journal: J Clin Psychiatry Date: 1985-09 Impact factor: 4.384

8. Comparison of the electrocardiographic effect of dothiepin and amitriptyline.

Authors: J L Claghorn; J Schroeder; B J Goldstein
Journal: J Clin Psychiatry Date: 1984-07 Impact factor: 4.384

9. Blood disorders and suicide in patients taking mianserin or amitriptyline.

Authors: W H Inman
Journal: Lancet Date: 1988-07-09 Impact factor: 79.321

10. A review of multicenter controlled studies of fluoxetine vs. imipramine and placebo in outpatients with major depressive disorder.

Authors: P Stark; C D Hardison
Journal: J Clin Psychiatry Date: 1985-03 Impact factor: 4.384

10 in total

Review 4. Fluoxetine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in older patients with depressive illness.

Authors: M G Harris; P Benfield
Journal: Drugs Aging Date: 1995-01 Impact factor: 3.923

The safety of antidepressants.

1. Do some antidepressants promote suicide?

2. A pharmacological profile of fluoxetine and other antidepressants on aspects of skilled performance and car handling ability.

3. Toxicity of antidepressants.

Review 4. TCA poisoning treated in the intensive care unit.

5. Statistical predictions of suicide in depressives.

6. Treatment of geriatric depression with trazodone, imipramine, and placebo: a double-blind study.

7. A comparative trial of fluoxetine and amitriptyline in patients with major depressive disorder.

8. Comparison of the electrocardiographic effect of dothiepin and amitriptyline.

9. Blood disorders and suicide in patients taking mianserin or amitriptyline.

10. A review of multicenter controlled studies of fluoxetine vs. imipramine and placebo in outpatients with major depressive disorder.

Review 1. Effects of psychotropic drugs on seizure threshold.

2. Trazodone for sleep disturbance during methadone maintenance: a double-blind, placebo-controlled trial.

Review 3. A risk-benefit assessment of mirtazapine in the treatment of depression.

Review 4. Fluoxetine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in older patients with depressive illness.

5. Paroxetine : a review of its pharmacology and therapeutic potential in the management of panic disorder.

Review 6. Antidepressant toxicity and the need for identification and concentration monitoring in overdose.

Review 7. Fluvoxamine. An updated review of its pharmacology, and therapeutic use in depressive illness.

Review 8. 'Atypical' antidepressants in overdose: clinical considerations with respect to safety.

Review 9. Clinical pharmacokinetics of fluvoxamine.

Review 10. Comparative tolerability profiles of the newer versus older antidepressants.