Literature DB >> 1378239

From records to self-description: the role played by RNA in early evolutive systems.

A Moreno Bergareche1, J Fernández Ostolaza.   

Abstract

We study the appearance of genetic information starting from a system where self-reproductive and enzymatic functions are supported by the same sort of molecules. In a first phase, the information must have arisen in the form of rate independent sequences as records of enzymatic functions. Although this stage must have played an important role in evolution, it will be shown how its evolutive capacities were blocked by the impossibility of appearance of geno/phenotype duality. Finally, a logical scheme is proposed for a transition process toward a system with a code offering a simplification of the conditions required from the assumption of a maximum use of the double RNA capacity, both reproductive and enzymatic.

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Year:  1992        PMID: 1378239     DOI: 10.1007/bf00046546

Source DB:  PubMed          Journal:  Acta Biotheor        ISSN: 0001-5342            Impact factor:   1.774


  11 in total

1.  A speculation on the origin of protein synthesis.

Authors:  F H Crick; S Brenner; A Klug; G Pieczenik
Journal:  Orig Life       Date:  1976-12

2.  Structural limits for evolutive capacities in complex molecular systems.

Authors:  A M Bergareche; J F Ostolaza
Journal:  Riv Biol       Date:  1990

Review 3.  Biological catalysis by RNA.

Authors:  T R Cech; B L Bass
Journal:  Annu Rev Biochem       Date:  1986       Impact factor: 23.643

4.  RNA catalysis and the origin of life.

Authors:  N R Pace; T L Marsh
Journal:  Orig Life Evol Biosph       Date:  1985       Impact factor: 1.950

Review 5.  RNA catalysis and the origins of life.

Authors:  L E Orgel
Journal:  J Theor Biol       Date:  1986-11-21       Impact factor: 2.691

6.  On the primacy of primordial RNA.

Authors:  R Cedergren; H Grosjean
Journal:  Biosystems       Date:  1987       Impact factor: 1.973

7.  Template-directed synthesis on the pentanucleotide CpCpGpCpC.

Authors:  T Inoue; G F Joyce; K Grzeskowiak; L E Orgel; J M Brown; C B Reese
Journal:  J Mol Biol       Date:  1984-09-25       Impact factor: 5.469

8.  The generation of complexity in evolution: a thermodynamic and information-theoretical discussion.

Authors:  J S Wicken
Journal:  J Theor Biol       Date:  1979-04-07       Impact factor: 2.691

9.  Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena.

Authors:  K Kruger; P J Grabowski; A J Zaug; J Sands; D E Gottschling; T R Cech
Journal:  Cell       Date:  1982-11       Impact factor: 41.582

10.  In vitro splicing of the ribosomal RNA precursor of Tetrahymena: involvement of a guanosine nucleotide in the excision of the intervening sequence.

Authors:  T R Cech; A J Zaug; P J Grabowski
Journal:  Cell       Date:  1981-12       Impact factor: 41.582

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