Literature DB >> 137810

On the influence of age on immunity in Down's syndrome.

R Seger, G Buchinger, J Ströder.   

Abstract

In 23 subjects of different ages with Down's syndrome a number of parameters of non-specific defense of humoral and cellular immunity were investigated. While in all age groups complement factors C3, C4 and C5 as well as phagocytosis and NBT indices were in the normal range, a dysgammaglobulinaemia increasing with age with a hyperglobulinaemia of the IgG, IgA and IgD types was found, sparing immunoglobulins IgM and IgE. In addition the transformation capacity of peripheral blood lymphocytes decreased with age. This is understood as the consequence of premature aging of the thymus-dependent immune system.

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Year:  1977        PMID： 137810     DOI： 10.1007/bf00477543

Source DB:  PubMed          Journal:  Eur J Pediatr        ISSN： 0340-6199            Impact factor:   3.183


  36 in total

1.  Mitogenic effect of phytohaemagglutinin at different ages.

Authors:  A V Pisciotta; D W Westring; C DePrey; B Walsh
Journal:  Nature       Date:  1967-07-08       Impact factor: 49.962

2.  Down's syndrome and immunoglobulins.

Authors:  J Kaldor; D Pitt
Journal:  J Ment Defic Res       Date:  1971-12

3.  Cell-mediated immune response in patients with Down's syndrome.

Authors:  R Szigeti; T Révész; D Schuler
Journal:  Acta Paediatr Acad Sci Hung       Date:  1974

4.  Response to stimulation in vitro of lymphocytes from patients with Down's syndrome.

Authors:  I Fowler; D R Hollingsworth; H Traurig
Journal:  Proc Soc Exp Biol Med       Date:  1973-11

5.  Serum IgE concentration in trisomy 21.

Authors:  V Lopez
Journal:  J Ment Defic Res       Date:  1974-06

6.  Increased leukocyte glycogen in Down's syndrome.

Authors:  Y Abul-Fadl; R B Scott
Journal:  Nature       Date:  1969-07-19       Impact factor: 49.962

7.  Serum protein fractions in patients with Down's syndrome (mongolism).

Authors:  E L Greene; I R Shenker; S Karelitz
Journal:  Am J Dis Child       Date:  1968-05

8.  Serum levels of immune globulins in health and disease: a survey.

Authors:  E R Stiehm; H H Fudenberg
Journal:  Pediatrics       Date:  1966-05       Impact factor: 7.124

9.  A familial deficiency of the phagocytosis-enhancing activity of serum related to a dysfunction of the fifth component of complement (C5).

Authors:  M E Miller; U R Nilsson
Journal:  N Engl J Med       Date:  1970-02-12       Impact factor: 91.245

10.  Defects in granulocyte function in various chromosome abnormalities (Down's-, Edwards'-, Cri-du-chat syndrome).

Authors:  R Seger; A Wildfeuer; G Buchinger; W Romen; D Catty; L Dybas; O Haferkamp; J Ströder
Journal:  Klin Wochenschr       Date:  1976-02-15
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  9 in total

1.  Immunity in Down's syndrome.

Authors:  R J Ablin
Journal:  Eur J Pediatr       Date:  1978-01-17       Impact factor: 3.183

2.  T cell response to anti-CD3 antibody in Down's syndrome.

Authors:  A Bertotto; C Arcangeli; S Crupi; I Marinelli; R Gerli; R Vaccaro
Journal:  Arch Dis Child       Date:  1987-11       Impact factor: 3.791

3.  Cell-mediated immunodeficiency in Down's syndrome: normal IL-2 production but inverted ratio of T cell subsets.

Authors:  R Karttunen; T Nurmi; J Ilonen; H M Surcel
Journal:  Clin Exp Immunol       Date:  1984-02       Impact factor: 4.330

4.  Immune function in patients with chromosome deletions.

Authors:  T Nurmi; M Uhari; S L Linna; S Silvennoinen-Kassinen; M Koskela; J Kiuttu; A Tiilikainen
Journal:  Clin Exp Immunol       Date:  1982-04       Impact factor: 4.330

5.  Immunodeficiency in Down's syndrome: T-lymphocyte subset imbalance in trisomic children.

Authors:  G R Burgio; A Lanzavecchia; R Maccario; A Vitiello; A Plebani; A G Ugazio
Journal:  Clin Exp Immunol       Date:  1978-08       Impact factor: 4.330

6.  Natural killer cell function in trisomy-21 (Down's syndrome).

Authors:  T Nurmi; K Huttunen; O Lassila; M Henttonen; A Säkkinen; S L Linna; A Tiilikainen
Journal:  Clin Exp Immunol       Date:  1982-03       Impact factor: 4.330

7.  Immunodeficiency in Down's syndrome: relationship between presence of human thyroglobulin antibodies and HBsAg carrier status.

Authors:  A G Ugazio; S D Jayakar; A F Marcioni; M Duse; V Monafo; F Pasquali; G R Burgio
Journal:  Eur J Pediatr       Date:  1977-10-12       Impact factor: 3.183

8.  Inflammatory and Immunological parameters in adults with Down syndrome.

Authors:  Maria Bf Trotta; João B Serro Azul; Mauricio Wajngarten; Simone G Fonseca; Anna C Goldberg; Jorge E Kalil
Journal:  Immun Ageing       Date:  2011-04-16       Impact factor: 6.400

Review 9.  Metabolism and possible health effects of aluminum.

Authors:  P O Ganrot
Journal:  Environ Health Perspect       Date:  1986-03       Impact factor: 9.031
  9 in total

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