The use of live vaccine for vaccination of human beings against brucellosis in the USSR.

The great majority of human brucellosis cases in the USSR are caused by contact with infected sheep and goats. Extensive action has been taken to prevent human infection and to reduce the incidence among farm animals, the main prophylactic measure in recent years being vaccination with live brucellosis vaccine. The author summarizes the steps leading to the development of a satisfactory vaccine and gives a brief description of the method of preparation. Discussing the results obtained, she states that there has been a nearly 60% reduction in the number of human cases over the period 1952-58.The subcutaneous route of administration is usually resorted to, but preliminary figures suggest that cutaneous vaccination is equally effective immunogenically, although in persons who have suffered from active brucellosis it causes strong reactions and may lead to exacerbation of the disease. Research is going forward into the development of a cutaneous vaccine capable of general use.