| Literature DB >> 1377953 |
Y Takaue1, T Abe, Y Kawano, A Hirao, A Yokobayashi, Y Okamoto, S Saito, T Shimizu, J Sato, T Watanabe.
Abstract
The concept of ex vivo expansion of the human progenitor cell population was tested in this study. In the presence of interleukin-3 and -6 we compared the abilities of various liquid culture conditions of human blood-derived hematopoietic progenitor cells to yield a suitable condition for the expansion of blood progenitor cells. Although the best result was obtained in the gastpermeable bag culture system, the enhancement effect (maximum of 3.8-fold for granulocyte/macrophage colony-forming units and 3.0-fold for erythroid burst-forming units) lasted for only a short period (less than 6 d). The results of this study are disappointing for clinical use, and attempts with currently available technology appear to be limited in their potential.Entities:
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Year: 1992 PMID： 1377953 DOI： 10.1007/bf01738299
Source DB: PubMed Journal: Ann Hematol ISSN： 0939-5555 Impact factor: 3.673