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Literature DB >> 13775110

On the role of ribonucleic acid in animal virus synthesis. II. Studies with ribonuclease.

Abstract

Ribonuclease is a highly active inhibitor of vaccinia virus multiplication in vitro in the chorioallantoic membrane removed from embryonated chicken eggs. It is also a highly active inhibitor of pock formation by vaccinia and herpes simplex viruses on the chorioallantoic membrane in vivo. Marked inhibitory effects were obtained with 12.5 microg. of RNase. However, complete inhibition was not obtained with several hundred micrograms of the enzyme. RNase caused no inactivation of the infectivity of vaccinia virus particles but it had a marked inhibitory effect on multiplication of this virus when administered many hours after infection of host cells had occurred. RNase also failed to inactivate the infectivity of herpes simplex virus particles. The results obtained indicate that ribonucleic acid is necessary for the multiplication of two DNA-containing viruses; i.e., vaccinia and herpes simplex.

Entities: Disease Species

Keywords: HERPES/virology; RIBONUCLEASE/pharmacology; RIBONUCLEIC ACID/metabolism; VACCINIA/virology

Mesh：

Substances：

Year: 1960 PMID： 13775110 PMCID： PMC2137258 DOI： 10.1084/jem.111.3.351

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

18 in total

10. Influenza virus multiplication in the chorioallantoic membrane in vitro: kinetic aspects of inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole.

Authors: I TAMM; D A TYRRELL
Journal: J Exp Med Date: 1954-12-01 Impact factor: 14.307

5 in total

1. Effect of 8-azaguanine on the synthesis of vaccinia virus.

Authors: J COGNIAUX-LE CLERC
Journal: Br J Exp Pathol Date: 1962-12

2. Poliovirus-induced RNA polymerase and the effects of virus-specific inhibitors on its production.

Authors: D BALTIMORE; H J EGGERS; R M FRANKLIN; I TAMM
Journal: Proc Natl Acad Sci U S A Date: 1963-06 Impact factor: 11.205

3. Demonstration of the sequential development of vaccinial antigens and virus in infected cells: observations with cytochemical and differential fluorescent procedures.

Authors: P C LOH; J L RIGGS
Journal: J Exp Med Date: 1961-07-01 Impact factor: 14.307

4. Observations on the fine structure of mature herpes simplex virus and on the composition of its nucleoid.

Authors: M A EPSTEIN
Journal: J Exp Med Date: 1962-01-01 Impact factor: 14.307

5. On the role of ribonucleic acid in animal virus synthesis. I. Studies with 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole.

Authors: I TAMM; M M NEMES; S OSTERHOUT
Journal: J Exp Med Date: 1960-03-01 Impact factor: 14.307

5 in total

On the role of ribonucleic acid in animal virus synthesis. II. Studies with ribonuclease.

1. Action of ribonuclease and ribonucleic acid on living amoebae.

2. Quantitative studies on the growth of herpes virus in HeLa cells.

3. Multiplication of vaccinia virus in the chorioallantoic membrane in vitro.

4. The action of ribonuclease on the multiplication of influenza viruses in the de-embryonated egg.

5. Enhancement of influenza virus multiplication by 5-methyl-2-D-ribobenzimidazole.

6. Action of ribonuclease on the multiplication of the influenza virus.

7. [Effect of ribonuclease on Asteria oocytes].

8. Effects of ribonuclease on the metabolism of living root-tip cells.

9. ISOLATION OF ADENOSINE AMINO ACID ESTERS FROM A RIBONUCLEASE DIGEST OF SOLUBLE, LIVER RIBONUCLEIC ACID.