Literature DB >> 1377089

Ethanol inhibition of N-methyl-D-aspartate-activated ion current in rat hippocampal neurons is not competitive with glycine.

R W Peoples1, F F Weight.   

Abstract

The interaction of ethanol with glycine at the N-methyl-D-aspartate (NMDA)-activated ion channel was investigated in voltage-clamped rat cultured hippocampal neurons. As shown previously, glycine increased, and ethanol inhibited, the NMDA-activated current in these cells. Concentration-response data for glycine (0.1-100 microM) indicate that the inhibition of NMDA-activated current by ethanol does not involve a competitive interaction with glycine. Thus, ethanol appears to inhibit NMDA-activated current at a locus different from the glycine modulatory site.

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Year:  1992        PMID： 1377089     DOI： 10.1016/0006-8993(92)90674-x

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  12 in total

1.  Ethanol inhibition of constitutively open N-methyl-D-aspartate receptors.

Authors:  Minfu Xu; C Thetford Smothers; James Trudell; John J Woodward
Journal:  J Pharmacol Exp Ther       Date:  2011-10-17       Impact factor: 4.030

2.  Differential effects of TM4 tryptophan mutations on inhibition of N-methyl-d-aspartate receptors by ethanol and toluene.

Authors:  C Thetford Smothers; John J Woodward
Journal:  Alcohol       Date:  2016-10-03       Impact factor: 2.405

3.  NMDA receptor characterization and subunit expression in rat cultured mesencephalic neurones.

Authors:  C Allgaier; P Scheibler; D Müller; T J Feuerstein; P Illes
Journal:  Br J Pharmacol       Date:  1999-01       Impact factor: 8.739

4.  Deletion of the N-terminal domain alters the ethanol inhibition of N-methyl-D-aspartate receptors in a subunit-dependent manner.

Authors:  Corigan T Smothers; Chun Jin; John J Woodward
Journal:  Alcohol Clin Exp Res       Date:  2013-07-26       Impact factor: 3.455

5.  Effects of ethanol on phosphorylation site mutants of recombinant N-methyl-D-aspartate receptors.

Authors:  Minfu Xu; Corigan Thetford Smothers; John J Woodward
Journal:  Alcohol       Date:  2010-12-15       Impact factor: 2.405

6.  Ethanol inhibition of recombinant NMDA receptors is not altered by coexpression of CaMKII-alpha or CaMKII-beta.

Authors:  Minfu Xu; L Judson Chandler; John J Woodward
Journal:  Alcohol       Date:  2008-06-17       Impact factor: 2.405

7.  Functional interactions of alcohol-sensitive sites in the N-methyl-D-aspartate receptor M3 and M4 domains.

Authors:  Hong Ren; Abdelghaffar K Salous; Jaclyn M Paul; Kaitlin A Lamb; Donard S Dwyer; Robert W Peoples
Journal:  J Biol Chem       Date:  2008-01-21       Impact factor: 5.157

8.  Disruption of S2-M4 linker coupling reveals novel subunit-specific contributions to N-methyl-d-aspartate receptor function and ethanol sensitivity.

Authors:  Benjamin A Hughes; John J Woodward
Journal:  Neuropharmacology       Date:  2015-11-11       Impact factor: 5.250

Review 9.  Pharmacological approaches to reducing craving in patients with alcohol use disorders.

Authors:  Carolina L Haass-Koffler; Lorenzo Leggio; George A Kenna
Journal:  CNS Drugs       Date:  2014-04       Impact factor: 5.749

10.  Dephosphorylation of GluN2B C-terminal tyrosine residues does not contribute to acute ethanol inhibition of recombinant NMDA receptors.

Authors:  Benjamin A Hughes; C Thetford Smothers; John J Woodward
Journal:  Alcohol       Date:  2013-01-26       Impact factor: 2.405
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