Literature DB >> 1376984

Cytotoxic effects of hexavalent chromium in cultured murine macrophages.

M M Christensen1, E Ernst, S Ellermann-Eriksen.   

Abstract

The in vitro effect of hexavalent chromium (CrVI) on mouse peritoneal macrophages was investigated. Our results demonstrate the existence of a threshold concentration of 2.5 microM of CrVI above which chromium affects the viability of macrophages in a concentration dependent manner. Morphological changes were seen with increasing concentrations of chromium. Evidence is presented that protein production (virus-induced interferon) in murine peritoneal macrophages was impaired by hexavalent chromium at low concentrations, while random migration and phagocytic activity were only affected at high concentrations of CrVI.

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Year:  1992        PMID： 1376984     DOI： 10.1007/bf01973630

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  21 in total

1.  Metabolism of Cr51 by animals as influenced by chemical state.

Authors:  W J VISEK; I B WHITNEY; U S KUHN; C L COMAR
Journal:  Proc Soc Exp Biol Med       Date:  1953-12

2.  Characterization of chromium effects on a rat liver epithelial cell line and their relevance to in vitro transformation.

Authors:  J A Briggs; R C Briggs
Journal:  Cancer Res       Date:  1988-11-15       Impact factor: 12.701

3.  Toxicity of metal ions to alveolar macrophages.

Authors:  V Castranova; L Bowman; P R Miles; M J Reasor
Journal:  Am J Ind Med       Date:  1980       Impact factor: 2.214

4.  Enhancement of glutathione levels in mouse peritoneal macrophages by sodium arsenite, cadmium chloride and glucose/glucose oxidase.

Authors:  S Bannai; H Sato; T Ishii; S Taketani
Journal:  Biochim Biophys Acta       Date:  1991-04-17

5.  Macrophage migration inhibition as a correlate of cell-mediated immunity to herpes simplex virus type 2 in mice.

Authors:  S C Mogensen
Journal:  Immunobiology       Date:  1982       Impact factor: 3.144

6.  Low level chromium (VI) inhalation effects on alveolar macrophages and immune functions in Wistar rats.

Authors:  U Glaser; D Hochrainer; H Klöppel; H Kuhnen
Journal:  Arch Toxicol       Date:  1985-09       Impact factor: 5.153

7.  Uptake of 51Cr-chromate by human erythrocytes-a role of glutathione.

Authors:  J Aaseth; J Alexander; T Norseth
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1982-04

8.  Autointerference in silver accumulation in macrophages without affecting phagocytic, migratory or interferon-producing capacity.

Authors:  S Ellermann-Eriksen; J Rungby; S C Mogensen
Journal:  Virchows Arch B Cell Pathol Incl Mol Pathol       Date:  1987

9.  The reduction of chromium (VI) to chromium (III) by glutathione: an intracellular redox pathway in the metabolism of the carcinogen chromate.

Authors:  H J Wiegand; H Ottenwälder; H M Bolt
Journal:  Toxicology       Date:  1984-12       Impact factor: 4.221

10.  Response of bovine alveolar macrophages in vitro to welding fume particles.

Authors:  L R White; A B Marthinsen; K Jakobsen; K B Eik-Nes
Journal:  Environ Health Perspect       Date:  1983-09       Impact factor: 9.031
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