Literature DB >> 1376753

Expression of transforming growth factor type beta on human epidermal dendritic cells.

M S Gruschwitz1, O P Hornstein.   

Abstract

Our study demonstrates that epidermal Langerhans cells (LC) of healthy human skin produce Transforming growth factor-beta (TGF-beta). This multipotent mediator might keep the immunocompetent LC in an "immature" stage, in which they are able to capture and process antigen. Development to potent antigen-presenting cells would become possible after migration from the epidermal network to the draining lymph node to stimulate (auto-)reactive T-cell clones.

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Year:  1992        PMID： 1376753     DOI： 10.1111/1523-1747.ep12611890

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   8.551


  7 in total

Review 1.  Dendritic cells: novel players in fibrosis and scleroderma.

Authors:  Theresa T Lu
Journal:  Curr Rheumatol Rep       Date:  2012-02       Impact factor: 4.592

2.  Keratinocyte-derived TGFβ is not required to maintain skin immune homeostasis.

Authors:  Yi Yang; Yukari Zenke; Toshiro Hirai; Daniel H Kaplan
Journal:  J Dermatol Sci       Date:  2019-05-07       Impact factor: 4.563

3.  Mesenchymal stem cells (MSCs) from scleroderma patients (SSc) preserve their immunomodulatory properties although senescent and normally induce T regulatory cells (Tregs) with a functional phenotype: implications for cellular-based therapy.

Authors:  P Cipriani; P Di Benedetto; V Liakouli; B Del Papa; M Di Padova; M Di Ianni; A Marrelli; E Alesse; R Giacomelli
Journal:  Clin Exp Immunol       Date:  2013-08       Impact factor: 4.330

Review 4.  Description of 12 cases of nephrogenic fibrosing dermopathy and review of the literature.

Authors:  Fabian A Mendoza; Carol M Artlett; Nora Sandorfi; Kevin Latinis; Sonsoles Piera-Velazquez; Sergio A Jimenez
Journal:  Semin Arthritis Rheum       Date:  2006-02       Impact factor: 5.532

5.  A role for endogenous transforming growth factor beta 1 in Langerhans cell biology: the skin of transforming growth factor beta 1 null mice is devoid of epidermal Langerhans cells.

Authors:  T A Borkowski; J J Letterio; A G Farr; M C Udey
Journal:  J Exp Med       Date:  1996-12-01       Impact factor: 14.307

6.  Accumulation of BDCA1⁺ dendritic cells in interstitial fibrotic lung diseases and Th2-high asthma.

Authors:  Alexandra M Greer; Michael A Matthay; Jasleen Kukreja; Nirav R Bhakta; Christine P Nguyen; Paul J Wolters; Prescott G Woodruff; John V Fahy; Jeoung-Sook Shin
Journal:  PLoS One       Date:  2014-06-10       Impact factor: 3.240

Review 7.  Upcoming treatments for morphea.

Authors:  Dan Wenzel; Nazgol-Sadat Haddadi; Khashayar Afshari; Jillian M Richmond; Mehdi Rashighi
Journal:  Immun Inflamm Dis       Date:  2021-07-17
  7 in total

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