Literature DB >> 13764874

A study of potential histidine decarboxylase inhibitors.

D MACKAY, D M SHEPHERD.   

Abstract

A series of compounds has been examined for ability to inhibit histidine decarboxylase. Histidine analogues having substituents in the imidazole ring showed a wide variation in potency, but these were all much less active than alpha-methyldopa [beta-(3,4-dihydroxyphenyl)-alpha-methylalanine], the most potent known inhibitor of histidine decarboxylase. Some tentative conclusions are drawn regarding the relationship between chemical structure and inhibitory activity.

Entities:  

Keywords:  DESMOLASES/antagonists; IMIDAZOLES/pharmacology

Mesh：

Substances：

Year:  1960        PMID： 13764874      PMCID： PMC1482398          DOI： 10.1111/j.1476-5381.1960.tb00279.x

Source DB:  PubMed          Journal:  Br J Pharmacol Chemother        ISSN： 0366-0826


  4 in total

1.  [The effects of hydrazine and guanylhydrazone derivatives on the activity of monoamine oxidase, diamine oxidase, DOPA decarboxylase and histidine decarboxylase].

Authors:  E WERLE; A SCHAUER; G HARTUNG
Journal:  Klin Wochenschr       Date:  1955-06-15

2.  A place for histamine in normal physiology.

Authors:  G KAHLSON
Journal:  Lancet       Date:  1960-01-09       Impact factor: 79.321

3.  Studies on mammalian histidine decarboxylase.

Authors:  N G WATON
Journal:  Br J Pharmacol Chemother       Date:  1956-06

4.  Inhibition of dihydroxy-phenylalanine decarboxylase by derivatives of phenylalanine.

Authors:  T L SOURKES
Journal:  Arch Biochem Biophys       Date:  1954-08       Impact factor: 4.013
  4 in total
  6 in total

1.  HISTIDINE DECARBOXYLASE IN HYALINE MEMBRANE DISEASE.

Authors:  R G MITCHELL
Journal:  Arch Dis Child       Date:  1964-02       Impact factor: 3.791

2.  OBSERVATIONS ON THE INHIBITION OF HISTAMINE FORMATION.

Authors:  G KAHLSON; E ROSENGREN; R THUNBERG
Journal:  J Physiol       Date:  1963-12       Impact factor: 5.182

3.  On the presence of different histidine decarboxylating enzymes in mammalian tissues.

Authors:  P O GANROT; A M ROSENGREN; E ROSENGREN
Journal:  Experientia       Date:  1961-06-15

4.  Histidine decarboxylase in the new-born human infant.

Authors:  R G Mitchell
Journal:  J Physiol       Date:  1963-04       Impact factor: 5.182

5.  The possible role of histamine in the coritsone induced gastric acid hypersecretion of the guinea-pig.

Authors:  S Heisler; E M Kovacs
Journal:  Br J Pharmacol       Date:  1969-03       Impact factor: 8.739

6.  Histamine and its metabolism in mammals. Part II: Catabolism of histamine and histamine liberation.

Authors:  C Maśliński
Journal:  Agents Actions       Date:  1975-08
  6 in total

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