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Literature DB >> 1375910

Small RNA helices as substrates for aminoacylation and their relationship to charging of transfer RNAs.

C Francklyn¹, K Musier-Forsyth, P Schimmel.

Abstract

RNA microhelices that reconstruct the acceptor stems of transfer RNAs can be aminoacylated. The anticodon-independent aminoacylation is sequence-specific and suggests a relationship between amino acids and nucleotide sequences which is different from that of the classical genetic code. The specific aminoacylation of RNA microhelices also suggests a highly differentiated adaptation of the structures of aminoacyl-tRNA synthetases to sequences in the acceptor stems of transfer RNAs.

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Year: 1992 PMID： 1375910 DOI： 10.1111/j.1432-1033.1992.tb16929.x

Source DB: PubMed Journal: Eur J Biochem ISSN： 0014-2956

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Cited

17 in total

1. Domain-domain communication in a miniature archaebacterial tRNA synthetase.

Authors: B A Steer; P Schimmel
Journal: Proc Natl Acad Sci U S A Date: 1999-11-23 Impact factor: 11.205

2. Assembly of a catalytic unit for RNA microhelix aminoacylation using nonspecific RNA binding domains.

Authors: J W Chihade; P Schimmel
Journal: Proc Natl Acad Sci U S A Date: 1999-10-26 Impact factor: 11.205

3. tRNA acceptor-stem and anticodon bases embed separate features of amino acid chemistry.

Authors: Charles W Carter; Richard Wolfenden
Journal: RNA Biol Date: 2015-11-23 Impact factor: 4.652

4. A biologically active 53 kDa fragment of overproduced alanyl-tRNA synthetase from Thermus thermophilus HB8 specifically interacts with tRNA Ala acceptor helix.

Authors: A Lechler; A Martin; T Zuleeg; S Limmer; R Kreutzer
Journal: Nucleic Acids Res Date: 1997-07-15 Impact factor: 16.971

Small RNA helices as substrates for aminoacylation and their relationship to charging of transfer RNAs.

1. Domain-domain communication in a miniature archaebacterial tRNA synthetase.

2. Assembly of a catalytic unit for RNA microhelix aminoacylation using nonspecific RNA binding domains.

3. tRNA acceptor-stem and anticodon bases embed separate features of amino acid chemistry.

4. A biologically active 53 kDa fragment of overproduced alanyl-tRNA synthetase from Thermus thermophilus HB8 specifically interacts with tRNA Ala acceptor helix.

5. Aminoacylating urzymes challenge the RNA world hypothesis.

6. tRNA acceptor stem and anticodon bases form independent codes related to protein folding.

Review 7. Urzymology: experimental access to a key transition in the appearance of enzymes.

Review 8. Coding of Class I and II Aminoacyl-tRNA Synthetases.

Review 9. An operational RNA code for amino acids and variations in critical nucleotide sequences in evolution.

10. Synthetic polyamines stimulate in vitro transcription by T7 RNA polymerase.