Literature DB >> 1375352

The cGMP-gated channel of rod outer segments is not localized in bipolar cells of the mammalian retina.

H Wässle1, U Grünert, N J Cook, R S Molday.   

Abstract

It has recently been suggested (Nature, 346 (1990) 269-271) that ON-bipolar cells express the same biochemical cascade and guanosine 3',5'-cyclic monophosphate (cGMP)-gated cation channel as rod outer segments. An antibody directed against the cGMP-gated channel of bovine rod outer segments was applied to cryostat sections of rat and cat retinae. No immunocytochemical labelling was found in bipolar cells. Therefore, if those cells express a cGMP-gated channel, it must be immunologically different to the 63 kDa protein constituting the cGMP-gated channel of the outer segment.

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Year:  1992        PMID: 1375352     DOI: 10.1016/0304-3940(92)90516-a

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN: 0304-3940            Impact factor:   3.046


  9 in total

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Review 3.  Regulation of ON bipolar cell activity.

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4.  Isolation and characterization of the alpha-subunit of the rat rod photoreceptor cGMP-gated cation channel.

Authors:  C J Barnstable
Journal:  J Mol Neurosci       Date:  1995       Impact factor: 3.444

5.  cGMP-mediated effects on the physiology of bovine and human retinal Müller (glial) cells.

Authors:  S Kusaka; I Dabin; C J Barnstable; D G Puro
Journal:  J Physiol       Date:  1996-12-15       Impact factor: 5.182

6.  The metabotropic receptor mGluR6 may signal through G(o), but not phosphodiesterase, in retinal bipolar cells.

Authors:  S Nawy
Journal:  J Neurosci       Date:  1999-04-15       Impact factor: 6.167

7.  The light-activated signaling pathway in SCN-projecting rat retinal ganglion cells.

Authors:  Erin J Warren; Charles N Allen; R Lane Brown; David W Robinson
Journal:  Eur J Neurosci       Date:  2006-05       Impact factor: 3.386

8.  The light response of ON bipolar neurons requires G[alpha]o.

Authors:  A Dhingra; A Lyubarsky; M Jiang; E N Pugh; L Birnbaumer; P Sterling; N Vardi
Journal:  J Neurosci       Date:  2000-12-15       Impact factor: 6.167

9.  Apoptosis in retinal degeneration involves cross-talk between apoptosis-inducing factor (AIF) and caspase-12 and is blocked by calpain inhibitors.

Authors:  Daniela Sanges; Antonella Comitato; Roberta Tammaro; Valeria Marigo
Journal:  Proc Natl Acad Sci U S A       Date:  2006-11-06       Impact factor: 11.205

  9 in total

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