| Literature DB >> 1375278 |
A B Hill1, A Müllbacher, C Parrish, G Coia, E G Westaway, R V Blanden.
Abstract
Cytotoxic T (Tc) cells were generated in mice of five H-2 haplotypes against the flaviviruses Kunjin and West Nile (WNV). A panel of recombinant vaccinia viruses which between them expressed cDNA of the entire Kunjin virus genome were used to infect targets. Anti-Kunjin virus responses to determinants derived from non-structural proteins, especially NS3, NS4A and NS4B, were dominant in most mouse strains; usually only one class I major histocompatibility complex (MHC) restriction element was involved. WNV-immune Tc cells showed similar but not identical patterns of antigen recognition to Kunjin virus-immune Tc cells. The extent to which WNV-immune Tc cells recognized Kunjin virus-encoded determinants varied considerably between mice of different MHC haplotypes.Entities:
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Year: 1992 PMID： 1375278 DOI： 10.1099/0022-1317-73-5-1115
Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891