Literature DB >> 137524

Complete reversal of experimental diabetes mellitus in rats by a single fetal pancreas.

Y S Mullen, W R Clark, I G Molnar, J Brown.   

Abstract

Complete reversal of streptozotocin-induced diabetes mellitus in adult rats will follow transplantation of a single fetal pancreas if the organ is first grown in a normal syngeneic carrier before transfer to the diabetic recipient. Careful control of the blood sugar of diabetic recipients may enhance the function of a single donor organ and thus improve histocompatibility matching.

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Year:  1977        PMID: 137524     DOI: 10.1126/science.137524

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  12 in total

1.  Fetal pancreas as a donor organ.

Authors:  J Brown; J A Danilovs; W R Clark; Y S Mullen
Journal:  World J Surg       Date:  1984-04       Impact factor: 3.352

2.  Normal response to pregnancy in rats cured of streptozotocin diabetes by transplantation of one fetal pancreas.

Authors:  J Brown; D Heininger; J Kuret; Y Mullen
Journal:  Diabetologia       Date:  1982-04       Impact factor: 10.122

3.  Transplantation of organ-cultured fetal pancreas: experimental studies and potential clinical application in diabetes mellitus.

Authors:  T E Mandel
Journal:  World J Surg       Date:  1984-04       Impact factor: 3.352

4.  Augmenter of liver regeneration enhances the success rate of fetal pancreas transplantation in rodents.

Authors:  G A Adams; M Maestri; E C Squiers; E J Alfrey; T E Starzl; D C Dafoe
Journal:  Transplantation       Date:  1998-01-15       Impact factor: 4.939

Review 5.  How to make a functional β-cell.

Authors:  Felicia W Pagliuca; Douglas A Melton
Journal:  Development       Date:  2013-06       Impact factor: 6.868

6.  Cryopreservation of fetal rat liver tissue--a morphological investigation.

Authors:  M Sawa; S Kasai; M Mito
Journal:  Jpn J Surg       Date:  1986-11

7.  Chick embryo pancreatic transplants reverse experimental diabetes of rats.

Authors:  R Eloy; K Haffen; M Kedinger; J F Grenier
Journal:  J Clin Invest       Date:  1979-08       Impact factor: 14.808

8.  Importance of hepatic portal circulation for insulin action in streptozotocin-diabetic rats transplanted with fetal pancreases.

Authors:  J Brown; Y Mullen; W R Clark; I G Molnar; D Heininger
Journal:  J Clin Invest       Date:  1979-12       Impact factor: 14.808

9.  Subcutaneous transplantation of embryonic pancreas for correction of type 1 diabetes.

Authors:  Subhadra C Gunawardana; Richard K P Benninger; David W Piston
Journal:  Am J Physiol Endocrinol Metab       Date:  2008-12-09       Impact factor: 4.310

10.  Long-term isografts of cultured fetal mouse pancreatic islets. The oncogenic effects of streptozotocin and the prevention of diabetic renal complications.

Authors:  T E Mandel; L Hoffman; W M Carter
Journal:  Am J Pathol       Date:  1981-09       Impact factor: 4.307

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