Literature DB >> 13747148

The relation of thyroid auto-immunity to round-celled infiltration of the thyroid gland.

R O SCHADE, S G OWEN, G A SMART, R HALL.   

Abstract

The relationship between thyroid auto-immunity and the presence of lymphocytes in the thyroid gland has been analysed in patients with Graves' disease, toxic adenoma, and non-toxic nodular goitre. In all these conditions circulating antibody to thyroglobulin was significantly associated with lymphocytic infiltration. No similar correlation was established in the case of the complement-fixing antibody.Complement-fixing antibody was significantly commoner in Graves' disease (diffuse thyrotoxic goitre) than in toxic adenoma and non-toxic nodular goitre. Circulating thyroglobulin antibody probably originates from lymphoid tissue within and around the thyroid gland itself. Overactivity of pituitary thyrotropin may favour immunization to the intracellular (complementfixing) antigen.

Entities:  

Keywords:  HYPERTHYROIDISM

Mesh：

Substances：

Year:  1960        PMID： 13747148      PMCID： PMC480129          DOI： 10.1136/jcp.13.6.499

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN： 0021-9746            Impact factor:   3.411


  9 in total

1.  Complement-fixing antithyroid antibodies in hospital patients with asymptomatic thyroid lesions.

Authors:  R B GOUDIE; J R ANDERSON; K G GRAY
Journal:  J Pathol Bacteriol       Date:  1959-04

2.  Investigations of thyroid antigens reacting with Hashimoto sera; evidence for an antigen other than thyroglobulin.

Authors:  G BELYAVIN; W R TROTTER
Journal:  Lancet       Date:  1959-03-28       Impact factor: 79.321

3.  Thyroid antibodies and thyroiditis.

Authors:  G A SMART; S G OWEN
Journal:  Postgrad Med J       Date:  1960-07       Impact factor: 2.401

4.  Human autoimmune thyroiditis: serological studies.

Authors:  I M ROITT; D DONIACH
Journal:  Lancet       Date:  1958-11-15       Impact factor: 79.321

5.  Thyroid antibodies in myxoedema.

Authors:  S G OWEN; G A SMART
Journal:  Lancet       Date:  1958-11-15       Impact factor: 79.321

6.  Cytotoxic effects of Hashimoto serum on human thyroid cells in tissue culture.

Authors:  R J PULVERTAFT; D DONIACH; I M ROITT; R V HUDSON
Journal:  Lancet       Date:  1959-08-29       Impact factor: 79.321

7.  Cytoplasmic localization of "complement-fixing" auto-antigen in human thyroid epithelium.

Authors:  E J HOLBOROW; P C BROWN; I M ROITT; D DONIACH
Journal:  Br J Exp Pathol       Date:  1959-12

8.  Precipitating and complement-fixing antibodies in Hashimoto's disease.

Authors:  W R TROTTER; G BELYAVIN; A WADDAMS
Journal:  Proc R Soc Med       Date:  1957-11

9.  The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera.

Authors:  S V BOYDEN
Journal:  J Exp Med       Date:  1951-02       Impact factor: 14.307
  9 in total
  7 in total

1.  THYROTOXICOSIS TREATED BY SURGERY OR IODINE-131. WITH SPECIAL REFERENCE TO DEVELOPMENT OF HYPOTHYROIDISM.

Authors:  M GREEN; G M WILSON
Journal:  Br Med J       Date:  1964-04-18

2.  Sarcoidosis and hyperthyroidism.

Authors:  J E STARK
Journal:  Proc R Soc Med       Date:  1963-07

3.  Experimental studies related to autoimmunity in myasthenia gravis.

Authors:  B M Kaufman; G Rushworth; R Wright
Journal:  J Neurol Neurosurg Psychiatry       Date:  1969-08       Impact factor: 10.154

4.  The incidence of thyroglobulin antibodies and thyroid enlargement in a general practice in north-east England.

Authors:  P R Dingle; A Ferguson; D B Horn; J Tubmen; R Hall
Journal:  Clin Exp Immunol       Date:  1966-07       Impact factor: 4.330

5.  Thyrotoxicosis in the African: clinical and immunological observations.

Authors:  P E McGill
Journal:  Br Med J       Date:  1971-06-19

6.  Pathogenetic relevance of HLA class II expressing thyroid follicular cells in nontoxic Goiter and in Graves' disease.

Authors:  B Grubeck-Loebenstein; M Londei; C Greenall; K Pirich; H Kassal; W Waldhäusl; M Feldmann
Journal:  J Clin Invest       Date:  1988-05       Impact factor: 14.808

7.  Correlation of fine needle aspiration cytology findings with thyroid function test in cases of lymphocytic thyroiditis.

Authors:  Neelam Sood; Jitendra Singh Nigam
Journal:  J Thyroid Res       Date:  2014-04-06
  7 in total

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