Literature DB >> 1374501

Age-related variations in relative abundance of alternative spliced D2 receptor mRNAs in brain areas of two rat strains.

F Della Vedova1, F Fumagalli, G Sacchetti, G Racagni, N Brunello.   

Abstract

Age-related reduction in the steady-state levels of messenger RNA for D2(415) and D2(444), the alternatively spliced form of dopamine D2 receptors, was observed in different rat brain areas using the sensitive reverse transcription (RT)-polymerase chain reaction (PCR) technique. In both Sprague-Dawley and Wistar aged rats, the decrease was more pronounced in the D2(444) isoform mRNA thus leading to a changed ratio in striatum as well as in the hippocampus.

Entities:  

Mesh:

Substances:

Year:  1992        PMID: 1374501     DOI: 10.1016/0169-328x(92)90140-7

Source DB:  PubMed          Journal:  Brain Res Mol Brain Res        ISSN: 0169-328X


  3 in total

1.  Effects of age, gender, and gonadectomy on neurochemistry and behavior in animal models of Parkinson's disease.

Authors:  Andrea Tamás; Andrea Lubics; István Lengvári; Dóra Reglodi
Journal:  Endocrine       Date:  2006-04       Impact factor: 3.633

2.  Aging of the striatum: mechanisms and interventions.

Authors:  Hiroyuki Umegaki; George S Roth; Donald K Ingram
Journal:  Age (Dordr)       Date:  2008-07-03

3.  CD28 costimulation regulates genome-wide effects on alternative splicing.

Authors:  Manish J Butte; Sun Jung Lee; Jonathan Jesneck; Mary E Keir; W Nicholas Haining; Arlene H Sharpe
Journal:  PLoS One       Date:  2012-06-29       Impact factor: 3.240

  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.