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Literature DB >> 13743575

Studies on immune cellular injury. I. Cytotoxic effects of antibody and complement.

Abstract

A model system for the investigation of immune cellular injury in primary isolates of a fixed-tissue cell of human origin has been described, using metabolism-inhibition and uptake of trypan blue as independent criteria of cytoxicity. Cytotoxic effects on human amnion cells were produced by the combination of specific rabbit antibody and factors in normal human serum which were indistinguishable from the components of hemolytic complement and calcium and magnesium ions. The data have been discussed in relation to the apparent multiplicity of serologic systems which can effect cellular injury. The nature of the cell and the source of antibody or normal serum constituents have been emphasized as factors which may influence the experimental selection of a given humoral mechanism.

Entities: Chemical Disease Species

Keywords: CYTOLOGY; IMMUNITY

Mesh：

Substances：

Year: 1960 PMID： 13743575 PMCID： PMC2137319 DOI： 10.1084/jem.112.6.1085

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

31 in total

1. Methods for measuring viability of ascites cells dye exclusion and respiration as affected by depletion, poisons, and viruses.

Authors: M D EATON; A R SCALA; M JEWELL
Journal: Cancer Res Date: 1959-10 Impact factor: 12.701

2. Cytopathogenic effect of antiserum to human malignant epithelial cells (strain HeLa) on HeLa cell culture.

Authors: I M MOUNTAIN
Journal: J Immunol Date: 1955-12 Impact factor: 5.422

3. Cytotoxic antibodies in the homograft reaction.

Authors: L SACHS; M FELDMAN
Journal: J Natl Cancer Inst Date: 1958-09 Impact factor: 13.506

4. The effects of heterologous immune serums upon HeLa cells in vitro and rat-HeLa tumors in vivo.

Authors: R M McALLISTER; P W GRUNMEIER; L L CORIELL; R R MARSHAK
Journal: J Natl Cancer Inst Date: 1958-09 Impact factor: 13.506

5. Cytotoxic effects of specific antiserum and 17-hydroxycorticosterone on cells in tissue culture.

Authors: A KUTSAKIS; H LATTA
Journal: Lab Invest Date: 1957 Jan-Feb Impact factor: 5.662

6. The properdin system and immunity. V. The bactericidal activity of the properdin system.

Authors: A C WARDLAW; L PILLEMER
Journal: J Exp Med Date: 1956-05-01 Impact factor: 14.307

7. EXPERIMENTAL STUDIES UPON LYMPHOCYTES : I. THE REACTIONS OF LYMPHOCYTES UNDER VARIOUS EXPERIMENTAL CONDITIONS.

Authors: A M Pappenheimer
Journal: J Exp Med Date: 1917-05-01 Impact factor: 14.307

8. The properdin system and immunity. III. The zymosan assay of properdin.

Authors: L PILLEMER; L BLUM; I H LEPOW; L WURZ; E W TODD
Journal: J Exp Med Date: 1956-01-01 Impact factor: 14.307

9. Studies on immune cellular injury. II. Functional role of C'1 esterase in immune cytotoxicity.

Authors: I H LEPOW; A ROSS
Journal: J Exp Med Date: 1960-12-01 Impact factor: 14.307

10. The cytotoxic action of immune gamma globulin and complement on Krebs ascites tumor cells. II. Chemical studies.

Authors: H GREEN; R A FLEISCHER; P BARROW; B GOLDBERG
Journal: J Exp Med Date: 1959-05-01 Impact factor: 14.307

11 in total

1. Cytotoxic effects produced by the beta toxin of Clostridium welchii on guinea-pigs monocytes.

Authors: D ALLAN
Journal: Immunology Date: 1963-01 Impact factor: 7.397

2. Development of bactericidal properties against gram-negative organisms in the serum of young animals.

Authors: J STERZL; J KOSTKA; A LANC
Journal: Folia Microbiol (Praha) Date: 1962-05 Impact factor: 2.099

3. Tissue culture studies of lymphoid tissue sensitized to skin homografts and explanted with donor tissue.

Authors: J A SHARP; R G BURWELL
Journal: J Anat Date: 1962-10 Impact factor: 2.610

4. Anti-nuclear factors and serum complement in systemic lupus erythematosus.

Authors: J H MORSE; H J MULLER-EBERHARD; H G KUNKEL
Journal: Bull N Y Acad Med Date: 1962-10

5. Hereditary deficiency of the second component of complement (C'2) in man.

Authors: M R Klemperer; H C Woodworth; F S Rosen; K F Austen
Journal: J Clin Invest Date: 1966-06 Impact factor: 14.808

6. Auto-allergic reactions following internal irradiation of the liver.

Authors: O J Wordsworth; P W Dykes
Journal: Immunology Date: 1969-12 Impact factor: 7.397

7. Immunhistological, microscopical and neurochemical studies on encephalitides. 3. Subacute progressive panencephalitis. Virological and immunhistological studies.

Authors: V ter Muelen; G Enders-Ruckle; D Müller; G Joppich
Journal: Acta Neuropathol Date: 1969 Impact factor: 17.088

8. Studies on immune cellular injury. II. Functional role of C'1 esterase in immune cytotoxicity.

Authors: I H LEPOW; A ROSS
Journal: J Exp Med Date: 1960-12-01 Impact factor: 14.307

9. The localization of in vivo bound complement in tissue section.

Authors: P J LACHMANN; H J MULLER-EBERHARD; H G KUNKEL; F PARONETTO
Journal: J Exp Med Date: 1962-01-01 Impact factor: 14.307

10. STUDIES ON IMMUNE HUMAN HEMOLYSIS : II. THE DONATH-LANDSTEINER REACTION AS A MODEL SYSTEM FOR STUDYING THE MECHANISM OF ACTION OF COMPLEMENT AND THE ROLE OF C'1 AND C'1 ESTERASE.

Authors: C F Hinz; M E Picken; I H Lepow
Journal: J Exp Med Date: 1961-01-01 Impact factor: 14.307