Literature DB >> 1374241

Hypotonic solution increases the slowly activating potassium current IsK expressed in xenopus oocytes.

A E Busch1, M Varnum, J P Adelman, R A North.   

Abstract

A slowly activating potassium current was expressed in Xenopus oocytes by injection of RNA transcribed from a rat kidney cDNA clone. Hypotonic solutions (160 mOsmol/l; control was 220 mOsmol/l) increased the current by increasing the rate of activation and by decreasing the depolarization needed to activate the current. This effect of hypotonicity was not observed in calcium-free solution, but was unaffected by staurosporine or the calmodulin antagonist W7. Cytochalasin D reduced the current and prevented the increase by hypotonic solution. The results suggest that the increase in this potassium current by hypotonic solution might result from calcium entry and changes in the actin network.

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Year:  1992        PMID： 1374241     DOI： 10.1016/0006-291x(92)90661-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  7 in total

1.  Activation of a nonselective cation channel by swelling in atrial cells.

Authors:  D Kim; C Fu
Journal:  J Membr Biol       Date:  1993-07       Impact factor: 1.843

2.  Osmolarity modulates K+ channel function on rat hippocampal interneurons but not CA1 pyramidal neurons.

Authors:  S C Baraban; M C Bellingham; A J Berger; P A Schwartzkroin
Journal:  J Physiol       Date:  1997-02-01       Impact factor: 5.182

3.  Characterisation of a cell swelling-activated K+-selective conductance of ehrlich mouse ascites tumour cells.

Authors:  M I Niemeyer; C Hougaard; E K Hoffmann; F Jorgensen; A Stutzin; F V Sepúlveda
Journal:  J Physiol       Date:  2000-05-01       Impact factor: 5.182

4.  A corticosteroid-induced gene expressing an "IsK-like" K+ channel activity in Xenopus oocytes.

Authors:  B Attali; H Latter; N Rachamim; H Garty
Journal:  Proc Natl Acad Sci U S A       Date:  1995-06-20       Impact factor: 11.205

5.  Swelling-activated chloride and potassium conductance in primary cultures of mouse proximal tubules. Implication of KCNE1 protein.

Authors:  H Barrière; I Rubera; R Belfodil; M Tauc; N Tonnerieux; C Poujeol; J Barhanin; P Poujeol
Journal:  J Membr Biol       Date:  2003-06-01       Impact factor: 1.843

6.  Hypo-osmotic challenge stimulates transepithelial K+ secretion and activates apical IsK channel in vestibular dark cells.

Authors:  P Wangemann; J Liu; Z Shen; A Shipley; D C Marcus
Journal:  J Membr Biol       Date:  1995-10       Impact factor: 1.843

7.  I(sK) Channel in Strial Marginal Cells. Voltage-Dependence, Ion-Selectivity, Inhibition by 293B and Sensitivity to Clofilium.

Authors:  Zhijun Shen; Daniel C Marcus; Hiroshi Sunose; Toshihiko Chiba; Philine Wangemann
Journal:  Audit Neurosci       Date:  1997
  7 in total

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