Literature DB >> 13740412

Effect of actinomycin D on cellular nucleic acid synthesis and virus production.

E REICH, R M FRANKLIN, A J SHATKIN, E L TATUM.   

Abstract

Actinomycin D inhibits the synthesis of ribonucleic acid in L cells and the yield of vaccinia virus containing deoxyribonucleic acid, but it does not inhibit cellular deoxyribonucleic acid synthesis or the multiplication of Mengo virus containing ribonucleic acid. These observations serve to distinguish the replication of viral ribonucleic from ribonucleic acid synthesis which is controlled by viral or cellular deoxyribonucleic acid.

Entities:  

Keywords:  ACTINOMYCIN/pharmacology; CYTOLOGY; NUCLEIC ACIDS/metabolism; VACCINIA/virology

Mesh：

Substances：

Year:  1961        PMID： 13740412     DOI： 10.1126/science.134.3478.556

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  123 in total

1.  XPB, a subunit of TFIIH, is a target of the natural product triptolide.

Authors:  Denis V Titov; Benjamin Gilman; Qing-Li He; Shridhar Bhat; Woon-Kai Low; Yongjun Dang; Michael Smeaton; Arnold L Demain; Paul S Miller; Jennifer F Kugel; James A Goodrich; Jun O Liu
Journal:  Nat Chem Biol       Date:  2011-01-30       Impact factor: 15.040

2.  INHIBITION OF RNA SYNTHESIS IN ESCHERICHIA COLI BY LEVORPHANOL.

Authors:  E J SIMON; D VANPRAAG
Journal:  Proc Natl Acad Sci U S A       Date:  1964-05       Impact factor: 11.205

3.  THE STABILITY OF LIVER MESSENGER RNA.

Authors:  M REVEL; H H HIATT
Journal:  Proc Natl Acad Sci U S A       Date:  1964-05       Impact factor: 11.205

4.  ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS.

Authors:  V G ALLFREY; R FAULKNER; A E MIRSKY
Journal:  Proc Natl Acad Sci U S A       Date:  1964-05       Impact factor: 11.205

5.  A PARADOXICAL EFFECT OF ACTINOMYCIN D: THE MECHANISM OF REGULATION OF ENZYME SYNTHESIS BY HYDROCORTISONE.

Authors:  L D GARREN; R R HOWELL; G M TOMKINS; R M CROCCO
Journal:  Proc Natl Acad Sci U S A       Date:  1964-10       Impact factor: 11.205

6.  Inhibition of the rejection of renal homografts in dogs by drugs.

Authors:  R Y CALNE
Journal:  Ann R Coll Surg Engl       Date:  1963-05       Impact factor: 1.891

7.  THE EFFECT OF ACTINOMYCIN ON RIBOSOME FORMATION IN HELA CELLS.

Authors:  M GIRARD; S PENMAN; J E DARNELL
Journal:  Proc Natl Acad Sci U S A       Date:  1964-02       Impact factor: 11.205

Review 8.  ENTEROVIRUS ENTRANCE INTO SPECIFIC HOST CELLS, AND SUBSEQUENT ALTERATIONS OF CELL PROTEIN AND NUCLEIC ACID SYNTHESIS.

Authors:  J J HOLLAND
Journal:  Bacteriol Rev       Date:  1964-03

9.  THE EFFECTS OF INHIBITORS OF MACROMOLECULAR BIOSYNTHESIS UPON THE PERSISTENT RHYTHM OF LUMINESCENCE IN GONYAULAX.

Authors:  M W KARAKASHIAN; J W HASTINGS
Journal:  J Gen Physiol       Date:  1963-09       Impact factor: 4.086

10.  THE ROLE OF RNA SYNTHESIS IN EARLY ESTROGEN ACTION.

Authors:  H UI; G C MUELLER
Journal:  Proc Natl Acad Sci U S A       Date:  1963-08       Impact factor: 11.205
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