Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The gene for a tRNA modifying enzyme, m5U54-methyltransferase, is essential for viability in Escherichia coli.

Literature DB >> 1373891

The gene for a tRNA modifying enzyme, m5U54-methyltransferase, is essential for viability in Escherichia coli.

B C Persson¹, C Gustafsson, D E Berg, G R Björk.

Abstract

One of the most abundant modified nucleosides in tRNA is 5-methyluridine (m5U or rT, ribothymidine). The enzyme tRNA(m5U54)methyltransferase [S-adenosyl-L-methionine:tRNA (uracil-5-)-methyltransferase, EC 2.1.1.35] (the trmA gene product) catalyzes S-adenosylmethionine-dependent methylation of the uracil in position 54 (T psi C loop) in all Escherichia coli tRNAs to form m5U. Hitherto no modified nucleoside in tRNA has been shown to be essential for growth, although their importance in fine tuning the function of tRNA is well established. In this paper, we show that the structural gene trmA is essential for viability, although the known catalytic activity of the tRNA(m5U54)methyltransferase is not.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1992 PMID： 1373891 PMCID： PMC525618 DOI： 10.1073/pnas.89.9.3995

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

33 in total

1. The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutants.

Authors: C Rayssiguier; D S Thaler; M Radman
Journal: Nature Date: 1989-11-23 Impact factor: 49.962

2. The physical map of the whole E. coli chromosome: application of a new strategy for rapid analysis and sorting of a large genomic library.

Authors: Y Kohara; K Akiyama; K Isono
Journal: Cell Date: 1987-07-31 Impact factor: 41.582

3. Non-autogenous control of ribosomal protein synthesis from the trmD operon in Escherichia coli.

Authors: P M Wikström; A S Byström; G R Björk
Journal: J Mol Biol Date: 1988-09-05 Impact factor: 5.469

Review 4. Transfer RNA modification.

Authors: G R Björk; J U Ericson; C E Gustafsson; T G Hagervall; Y H Jönsson; P M Wikström
Journal: Annu Rev Biochem Date: 1987 Impact factor: 23.643

5. Transductional mapping of gene trmA responsible for the production of 5-methyluridine in transfer ribonucleic acid of Escherichia coli.

Authors: G R Björk
Journal: J Bacteriol Date: 1975-10 Impact factor: 3.490

6. Codon recognition patterns as deduced from sequences of the complete set of transfer RNA species in Mycoplasma capricolum. Resemblance to mitochondria.

Authors: Y Andachi; F Yamao; A Muto; S Osawa
Journal: J Mol Biol Date: 1989-09-05 Impact factor: 5.469

7. On the role of ribosylthymine in prokaryotic tRNA function.

Authors: H Kersten; M Albani; E Männlein; R Praisler; P Wurmbach; K H Nierhaus
Journal: Eur J Biochem Date: 1981-02

8. Defects in modification of cytoplasmic and mitochondrial transfer RNAs are caused by single nuclear mutations.

Authors: A K Hopper; A H Furukawa; H D Pham; N C Martin
Journal: Cell Date: 1982-03 Impact factor: 41.582

9. Efficient introduction of cloned mutant alleles into the Escherichia coli chromosome.

Authors: S Kulakauskas; P M Wikström; D E Berg
Journal: J Bacteriol Date: 1991-04 Impact factor: 3.490

10. The trmA promoter has regulatory features and sequence elements in common with the rRNA P1 promoter family of Escherichia coli.

Authors: C Gustafsson; P H Lindström; T G Hagervall; K B Esberg; G R Björk
Journal: J Bacteriol Date: 1991-03 Impact factor: 3.490

46 in total

1. Comparative genomics and evolution of proteins involved in RNA metabolism.

Authors: Vivek Anantharaman; Eugene V Koonin; L Aravind
Journal: Nucleic Acids Res Date: 2002-04-01 Impact factor: 16.971

2. Expression of the murine RanBP1 and Htf9-c genes is regulated from a shared bidirectional promoter during cell cycle progression.

Authors: G Guarguaglini; A Battistoni; C Pittoggi; G Di Matteo; B Di Fiore; P Lavia
Journal: Biochem J Date: 1997-07-01 Impact factor: 3.857

3. NMR solution structure of poliovirus uridylyated peptide linked to the genome (VPgpU).

Authors: Catherine H Schein; Numan Oezguen; Gerbrand J van der Heden van Noort; Dmitri V Filippov; Aniko Paul; Eric Kumar; Werner Braun
Journal: Peptides Date: 2010-05-02 Impact factor: 3.750

4. Structural and functional characterization of CFE88: evidence that a conserved and essential bacterial protein is a methyltransferase.

Authors: Keith L Constantine; Stanley R Krystek; Matthew D Healy; Michael L Doyle; Nathan O Siemers; Jane Thanassi; Ning Yan; Dianlin Xie; Valentina Goldfarb; Joseph Yanchunas; Li Tao; Brian A Dougherty; Bennett T Farmer
Journal: Protein Sci Date: 2005-06 Impact factor: 6.725

5. The methylthio group (ms2) of N6-(4-hydroxyisopentenyl)-2-methylthioadenosine (ms2io6A) present next to the anticodon contributes to the decoding efficiency of the tRNA.

Authors: B Esberg; G R Björk
Journal: J Bacteriol Date: 1995-04 Impact factor: 3.490

10. N7-Methylguanine at position 46 (m7G46) in tRNA from Thermus thermophilus is required for cell viability at high temperatures through a tRNA modification network.

Authors: Chie Tomikawa; Takashi Yokogawa; Tamotsu Kanai; Hiroyuki Hori
Journal: Nucleic Acids Res Date: 2009-11-24 Impact factor: 16.971