Literature DB >> 1373829

The genotoxicity of chromium(VI) oxide in the wing spot test of Drosophila melanogaster is over 90% due to mitotic recombination.

U Graf1, O S Heo, O O Ramirez.   

Abstract

Chromium(VI) oxide and chromium(III) chloride were tested in the wing somatic mutation and recombination test (SMART) in Drosophila melanogaster according to standard procedures. The hexavalent compound was highly genotoxic in both chronic and acute treatments whereas the trivalent one was clearly negative. Further analysis of wings carrying an inversion chromosome which eliminates all recombination events showed that over 90% of the spots induced by chromium(VI) oxide are due to mitotic recombination.

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Year:  1992        PMID: 1373829     DOI: 10.1016/0027-5107(92)90187-7

Source DB:  PubMed          Journal:  Mutat Res        ISSN: 0027-5107            Impact factor:   2.433


  3 in total

1.  Induced chromosomal exchange directs the segregation of recombinant chromatids in mitosis of Drosophila.

Authors:  K J Beumer; S Pimpinelli; K G Golic
Journal:  Genetics       Date:  1998-09       Impact factor: 4.562

2.  Analysis of the relationship between age of larvae at mutagen treatment and frequency and size of spots in the wing somatic mutation and recombination test in Drosophila melanogaster.

Authors:  U Graf
Journal:  Experientia       Date:  1995-02-15

3.  Nutritional supplement chromium picolinate causes sterility and lethal mutations in Drosophila melanogaster.

Authors:  Dion D D Hepburn; Jiarong Xiao; Sharell Bindom; John B Vincent; Janis O'Donnell
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-20       Impact factor: 11.205

  3 in total

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