Literature DB >> 1373752

Infectious respiratory syncytial virus (RSV) effectively inhibits the proliferative T cell response to inactivated RSV in vitro.

F M Preston1, P L Beier, J H Pope.   

Abstract

The effect of respiratory syncytial virus (RSV) on the cellular immune response of human mononuclear cells in vitro was examined. Inhibition by RSV of the lymphocyte response to phytohemagglutinin in vitro was confirmed using cells from human umbilical cord blood. In addition, RSV significantly inhibited both the proliferative and T cell colony responses of human mononuclear cells to Epstein-Barr virus. An RSV-specific cellular immune response was induced in vitro by stimulation of mononuclear cells from RSV-seropositive donors with beta-propiolactone-inactivated RSV. This RSV-specific response was significantly inhibited by infectious RSV itself, and the inhibition was mediated by an extracellular factor produced by RSV-infected mononuclear cells. A similar inhibition in vivo of the RSV-induced cellular immune response may contribute significantly to delayed recovery from primary infection and to reduced resistance to subsequent infections.

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Year:  1992        PMID： 1373752     DOI： 10.1093/infdis/165.5.819

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  9 in total

1.  Alpha and lambda interferon together mediate suppression of CD4 T cells induced by respiratory syncytial virus.

Authors:  Bo Chi; Harold L Dickensheets; Kirsten M Spann; Marc A Alston; Cindy Luongo; Laure Dumoutier; Jiaying Huang; Jean-Christophe Renauld; Sergei V Kotenko; Mario Roederer; Judy A Beeler; Raymond P Donnelly; Peter L Collins; Ronald L Rabin
Journal:  J Virol       Date:  2006-05       Impact factor: 5.103

2.  Respiratory syncytial virus glycoprotein G interacts with DC-SIGN and L-SIGN to activate ERK1 and ERK2.

Authors:  Teresa R Johnson; Jason S McLellan; Barney S Graham
Journal:  J Virol       Date:  2011-11-16       Impact factor: 5.103

3.  Subversion of pulmonary dendritic cell function by paramyxovirus infections.

Authors:  Antonieta Guerrero-Plata; Deepthi Kolli; Chao Hong; Antonella Casola; Roberto P Garofalo
Journal:  J Immunol       Date:  2009-03-01       Impact factor: 5.422

4.  Effects of human respiratory syncytial virus, metapneumovirus, parainfluenza virus 3 and influenza virus on CD4+ T cell activation by dendritic cells.

Authors:  Cyril Le Nouën; Philippa Hillyer; Shirin Munir; Christine C Winter; Thomas McCarty; Alexander Bukreyev; Peter L Collins; Ronald L Rabin; Ursula J Buchholz
Journal:  PLoS One       Date:  2010-11-29       Impact factor: 3.240

5.  Primary human mDC1, mDC2, and pDC dendritic cells are differentially infected and activated by respiratory syncytial virus.

Authors:  Teresa R Johnson; Christina N Johnson; Kizzmekia S Corbett; Gretchen C Edwards; Barney S Graham
Journal:  PLoS One       Date:  2011-01-28       Impact factor: 3.240

6.  Prophylaxis with a respiratory syncytial virus (RSV) anti-G protein monoclonal antibody shifts the adaptive immune response to RSV rA2-line19F infection from Th2 to Th1 in BALB/c mice.

Authors:  Seyhan Boyoglu-Barnum; Tatiana Chirkova; Sean O Todd; Thomas R Barnum; Kelsey A Gaston; Patricia Jorquera; Lia M Haynes; Ralph A Tripp; Martin L Moore; Larry J Anderson
Journal:  J Virol       Date:  2014-07-02       Impact factor: 5.103

7.  Decreased interferon-gamma response in respiratory syncytial virus compared to other respiratory viral infections in infants.

Authors:  J H Aberle; S W Aberle; W Rebhandl; E Pracher; M Kundi; T Popow-Kraupp
Journal:  Clin Exp Immunol       Date:  2004-07       Impact factor: 4.330

8.  A chimeric A2 strain of respiratory syncytial virus (RSV) with the fusion protein of RSV strain line 19 exhibits enhanced viral load, mucus, and airway dysfunction.

Authors:  Martin L Moore; Michael H Chi; Cindy Luongo; Nicholas W Lukacs; Vasiliy V Polosukhin; Matthew M Huckabee; Dawn C Newcomb; Ursula J Buchholz; James E Crowe; Kasia Goleniewska; John V Williams; Peter L Collins; R Stokes Peebles
Journal:  J Virol       Date:  2009-02-11       Impact factor: 5.103

9.  Lymphocyte apoptosis in acute respiratory syncytial virus bronchiolitis.

Authors:  M F E Roe; D M Bloxham; D K White; R I Ross-Russell; R T C Tasker; D R O'Donnell
Journal:  Clin Exp Immunol       Date:  2004-07       Impact factor: 4.330
  9 in total

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